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<原著>ウルソデスオキシコール酸の肝3-hydroxy-3-methylglutaryl coenzyme A reductaseと肝コレステロール7α-hydroxylase活性におよぼす作用
https://hsuh.repo.nii.ac.jp/records/6692
https://hsuh.repo.nii.ac.jp/records/6692965cf76f-d6da-4d65-90b3-96fda547ab0a
名前 / ファイル | ライセンス | アクション |
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<原著>ウルソデスオキシコール酸の肝3-hydroxy-3-methylglutaryl coenzyme A reductaseと肝コレステロール7α-hydroxylase活性におよぼす作用 (300.0 kB)
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Item type | 紀要論文(ELS) / Departmental Bulletin Paper(ELS)(1) | |||||
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公開日 | 1982-12-31 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | <原著>ウルソデスオキシコール酸の肝3-hydroxy-3-methylglutaryl coenzyme A reductaseと肝コレステロール7α-hydroxylase活性におよぼす作用 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | <ORIGINAL ARTICLE>Effects of Ursodesoxycholic Acid on 3-hydroxy-3-methylglutaryl Coenzyme A Reductase and Cholesterol 7α-hydroxylase Activity in Mice Liver Microsomes | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Ursodesoxycholic acid | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | HMG-CoA reductase | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | cholesterol 7α-hydroxylase | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ページ属性 | ||||||
内容記述タイプ | Other | |||||
内容記述 | P(論文) | |||||
言語 | ja | |||||
著者名(日) |
中村, 治雄
× 中村, 治雄× 倉橋, 昌司× 吉田, 昌江× 猪股, 孝四郎 |
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著者所属(日) | ||||||
ja | ||||||
東日本学園大学歯学部口腔生理学講座 | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Oral Physiology, School of Dentistry,HIGASHI-NIPPON-GAKUEN UNIVERSITY | ||||||
抄録(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | The activity of hepatic 3-hydroxy-3-methylglutaryl-CoA(HMG-CoA) reductase and 7α-hydroxylase, which are the enzymes controlling the rate of hepatic synthesis respe-ctively, in the cholesterol and bile acids were studied in mice receiving ursodesoxycholic acid (0.5% of the diet) for 10days and in the microsomal fraction containing 10-4M ursodesoxycholic acid in vitro. Both the activities of HMG-CoA reductase and cholesterol 7α-hydroxylase were reduced in vivo and in vitro.On the basis these findings, it is suggested that the decreased rate of cholesterol synthesis and cholesterol degradation to bile acid may play a significant role in the elimination of cholesterol in the serum and liver after ursodesoxycholic acid feeding. | |||||
雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN0008135X | |||||
書誌情報 |
ja : 東日本歯学雑誌 巻 1, 号 1, p. 39-43, 発行日 1982-12-31 |
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出版タイプ | ||||||
出版タイプ | VoR |