WEKO3
-
RootNode
アイテム
メラトニンの経口投与が骨代謝に及ぼす影響
https://hsuh.repo.nii.ac.jp/records/8692
https://hsuh.repo.nii.ac.jp/records/86921ab2520d-70c2-40dc-8b15-33dadcbc4442
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
メラトニンの経口投与が骨代謝に及ぼす影響 (2.4 MB)
|
|
| Item type | 紀要論文(ELS) / Departmental Bulletin Paper(ELS)(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2001-12-31 | |||||
| タイトル | ||||||
| タイトル | メラトニンの経口投与が骨代謝に及ぼす影響 | |||||
| 言語 | ja | |||||
| タイトル | ||||||
| タイトル | Effects of oral administration of melatonin on bone metabolism | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Melatonin | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Oral administration | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Bone metabolism | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| ページ属性 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | P(論文) | |||||
| 言語 | ja | |||||
| 記事種別(日) | ||||||
| ja | ||||||
| 原著 | ||||||
| 記事種別(英) | ||||||
| en | ||||||
| ORIGINAL REPORT | ||||||
| 著者名(日) |
政所, 明弘
× 政所, 明弘× 中出, 修× 服部, 裕歩× 賀来, 亨× 五十嵐, 清治 |
|||||
| 著者所属(日) | ||||||
| ja | ||||||
| 北海道医療大学歯学部小児歯科学講座 | ||||||
| 著者所属(日) | ||||||
| ja | ||||||
| 北海道医療大学歯学部口腔病理学講座 | ||||||
| 著者所属(英) | ||||||
| en | ||||||
| Department of Pediatric Dentistry, School of Dentistry, Health Sciences University of Hokkaido | ||||||
| 著者所属(英) | ||||||
| en | ||||||
| Department of Oral Pathology, School of Dentistry, Health Sciences University of Hokkaido | ||||||
| 抄録(英) | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | We have recently demonstrated that melatonin stimulates proliferation and type I collagen synthesis of normal human osteoblastic cells in vitro. We have further shown that daily I.P. injection of melatonin could increase cancellous bone mass in young growing mice in vivo, indicating that melatonin may possess beneficial effects on bone. The present study was to determine the effects of oral administration of melatonin on bone in vivo. In addition, we examined the effects of melatonin (1 to 500μM) on osteoclastic activity using dentin-resorption-pit assay formed in vitro and the results were as follows. 1. Oral administration of melatonin (0.1 or 1 %) did not significantly affect the body weight of the mice. 2. Oral melatonin did not cause any pathological changes in several internal organs including hearts, lungs, liver, kidneys and spleen in mice. 3. Oral melatonin did not significantly affect either length or width of femur or tibia in mice. 4. Bone histomorphometric analyses of the proximal tibia indicated that oral melatonin significantly increased the cancellous bone volume. 5. Oral melatonin significantly decreased the bone formation parameters such as osteoblast surface and osteoid volume and at the same time it significantly decreased the resorption parameters such as resorption surface and osteoclast number. 6. Melatonin (25 to 500 μM), in vitro, caused dose-dependent reduction in number of resorption pits formed by osteoclasts derived from bone marrow cells but not those formed by purified rabbit osteoclasts. These results indicate for the first time that oral administration of melatonin could increase cancellous bone mass in young growing mice, most likely by suppressing bone resorption through indirect modulation of osteoblastic secretory factors. | |||||
| 言語 | en | |||||
| 雑誌書誌ID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN0008135X | |||||
| 書誌情報 |
ja : 東日本歯学雑誌 巻 20, 号 2, p. 145-158, 発行日 2001-12-31 |
|||||
