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<原著>Growth Differentiation Factor-5/β-TCP複合体によるビーグル犬前頭洞内骨形成に関する実験的研究 <ORIGINAL REPORT>An experimental study of bone formation in the beagl dog frontal sinus induced by β-tricalcium phosphate matrix with growth differentiation factor-5 implants ja 國安, 宏哉 広瀬, 由紀人 賀来, 亨 金子, 昌幸 田隈, 泰信 GDF-5 β-TCP Sinus Lift Beagle Dog Frontal Sinus P(論文) This study assessed the efficacy and technical feasibility of inducing bone formation in an animal model of maxillary sinus floor augmentation using β-tricalcium phosphate (β-TCP) matrix with recombinant human growth differentiation factor 5 (rhGDF-5). The study used adult beagle dogs weighing 10 to 12 kg. The composite of the β-TCP matrix with rhGDF-5 (rhGDF-5/β-TCP) is made of approximately 300 micro-meter β-TCP particles and rhGDF-5 which contained 500 micro-gram per gram of β-TCP particles. Exposure of the frontal sinus was carried out bilaterally, with one sinus receiving 2 grams of the rhGDF-5/β-TCP implant and the other receiving 2 grams of β-TCP particles alone (control) . The frontal sinuses were excised 1, 2, 4, 8, 12, and 16 weeks after surgery and the bone formation in response to the rhGDF-5/β-TCP implant was evaluated histologically. At 2 weeks of postimplantation in the site implanted with rhGDF-5/β-TCP, new cancellous bone appeared at localized sites on the original bone surface. In contrast, there was no evidence of new bone formation at the control implant site. At 8 weeks, interconnected trabecular structure and bone marrow were found within the sinus of the rhGDF-5/β-TCP implants. Cartilage was not found in any region and residues of carrier β-TCP were seen in the middle area. At the site of the received controlimplants, the bulk of implanted β-TCP particles remained within the sinus. At 12 weeks, the large new trabecular bone extended to the original bone surfaces in the center of the implant site of the rhGDF-5/β-TCP implants. At the control site, little new cancellous bone was formed in the middle area. At 16 weeks, rhGDF-5/β-TCP implants increased new bone formation with the lapse of time and β-TCP particles were almost all absorbed. The present study showed that rhGDF-5 coated on β-TCP matrix successfully it maybe induced bone formation in the floor of the frontal sinus in a suitable animal model. Therfore, we conclude that the β-TCP matrix with rhGDF-5 could provide an acceptable biomaterial for maxillary sinus floor augmentation. 2002-06-30 jpn departmental bulletin paper https://hsuh.repo.nii.ac.jp/records/8711 AN0008135X 東日本歯学雑誌 21 1 11 23 https://hsuh.repo.nii.ac.jp/record/8711/files/KJ00000095983.pdf application/pdf 1.5 MB 2002-06-30