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咀嚼の有無がアミロイドβおよびβセクレターゼに与える影響
https://hsuh.repo.nii.ac.jp/records/2000569
https://hsuh.repo.nii.ac.jp/records/2000569929996f5-f764-4b00-8968-fffac9f95c9d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
咀嚼の有無がアミロイドβおよびβセクレターゼに与える影響 (7.2 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||||||||||||||
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| 公開日 | 2025-11-05 | |||||||||||||||||||||
| タイトル | ||||||||||||||||||||||
| タイトル | 咀嚼の有無がアミロイドβおよびβセクレターゼに与える影響 | |||||||||||||||||||||
| 言語 | ja | |||||||||||||||||||||
| タイトル | ||||||||||||||||||||||
| タイトル | Effect of Chewing on amyloid beta and beta secretase | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 言語 | ||||||||||||||||||||||
| 言語 | jpn | |||||||||||||||||||||
| 著者 |
石川, 啓延
× 石川, 啓延
× 豊下, 祥史
× 菅, 悠希
× 越野, 寿
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| キーワード | ||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | Chewing | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | Alzheimer disease | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | Amyloid beta | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | β−secretase | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | γ−secretase | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | Neprilysin | |||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||||||
| 抄録 | ||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||
| 内容記述 | Alzheimer’s disease (AD) is a common form of dementia characterized by progressive neuronal dysfunction with cognitive impairment and memory loss. Pathological findings in AD include senile plaques, which are deposits of mature amyloid beta (Aβ) fibers, and neurofibrillary tangles (NFT), which are aggregates of hyperphosphorylated tau. Aβ, in particular, is considered to be central to the pathogenesis of AD. Aβ is insoluble when deposited as mature fibers in brain tissue, but is soluble in the monomeric and oligomeric stages before maturation. These soluble oligomers are believed to be involved in the pathogenesis of AD, which eventually forms senile plaques. Aβ has various subtypes, such as Aβ40 and Aβ42, and Aβ42 is believed to play a major role in the development of AD. It is possible that Chewing influences the early signs of AD. In this study, we investigated whether Chewing affects the production of Aβ, a key enzyme in the development of AD, and the concentrations of β−secretase and γ−secretase and their degrading enzyme, neprilysin (NEP), in the central tissues, and examined whether Chewing may contribute to the prevention of AD. Experimental animals were 9−week−old male wild−type Wister/ST rats. After 3 months of rearing on each diet, the rats were euthanized with isoflurane, and cerebrospinal fluid and brain tissues were collected. The brain tissues were collected as a single mass, and divided into 5 parts : cerebellum, medulla oblongata, hypothalamus, mesencephalon−hippocampus−striatum complex, and cerebral cortex. The number of Aβ oligomers deposited in the cerebral cortex and the concentrations of Aβ42 and β−secretase in the cerebellum were significantly lower in the chewing group than in the non−chewing group. These results suggest that Chewing may contribute to the prevention of AD by inhibiting the production of β−secretase, a synthetic enzyme, and at the same time inhibiting the production of Aβ42. |
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| 言語 | en | |||||||||||||||||||||
| bibliographic_information |
ja : 北海道医療大学歯学雑誌 en : The Dental Journal of Health Sciences University of Hokkaido 巻 44, 号 1, p. 1-11, 発行日 2025-06-30 |
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| item_10002_source_id_9 | ||||||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||||||
| 収録物識別子 | 18805892 | |||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||
