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The effect of mastication on glucose metabolism via adiponectin in mice. An in Vivo study.
https://hsuh.repo.nii.ac.jp/records/2000572
https://hsuh.repo.nii.ac.jp/records/2000572b18502d6-6456-4fac-91dc-f65b8ea53a82
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
The effect of mastication on glucose metabolism via adiponectin in mice. An in Vivo study. (2.6 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||||||||||
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| 公開日 | 2025-11-05 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | The effect of mastication on glucose metabolism via adiponectin in mice. An in Vivo study. | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
| 著者 |
Yuki, KAN
× Yuki, KAN
× Yoshifumi, TOYOSHITA
× Katsuya, KAWANISHI
× Kenji, YOKOZEKI
× Sari, TAKADA
× Hisashi, KOSHINO
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| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | Mastication | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | Adiponectin | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | Leptin | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | Insulin sensitivity | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||||||||
| アクセス権 | ||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||
| 抄録 | ||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||
| 内容記述 | Aims : Mastication is reported as a factor that controls glucose metabolism. The aim of this study is to investigate whether mastication affects glucose metabolism through adiponectin and/or leptin, which play key roles in maintaining glucose metabolic homeostasis. Materials and Methods : Male C57BL/6J mice (4 weeks old) were divided randomly into two groups : the non−masticatory group (n=10), which received liquid diet, and the masticatory group ( n = 10 ) , which received solid diet. After 12 weeks, the mice were fasted for 24 hours, followed by a glucose tolerance test in which 2 g/kg glucose was administered. Three days later, the mice were anesthetized with 4% isoflurane, and blood was collected via cardiac puncture. Serum levels of adiponectin and leptin were measured using ELISA. We calculated Incremental Area under the Curve (IAUC) trapezoid rule according to methods described by Wolever. Data from both groups were analyzed using the Mann−Whitney U test, with p < 0.05 considered statistically significant. Results : The serum concentration of adiponectin was 55.9 ± 16.6 ng/mL in the masticatory group and 32.1 ± 19.1 ng/mL in the non−masticatory group. The masticatory group exhibited a significantly higher adiponectin concentration compared to the non−masticatory group (p < 0.05). In contrast, serum leptin levels had no significant difference in both groups. In the glucose tolerance test, the blood glucose level at 120 minutes post−administration was significantly higher in the non−masticatory group compared to the masticatory group. IAUC in the non−masticatory group were significantly higher than in the masticatory group. Conclusions : This study suggests that mastication increases adiponectin secretion and maintains insulin sensitivity, thereby preventing impaired glucose tolerance. |
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| 言語 | en | |||||||||||||||||
| bibliographic_information |
ja : 北海道医療大学歯学雑誌 en : The Dental Journal of Health Sciences University of Hokkaido 巻 44, 号 1, p. 31-36, 発行日 2025-06-30 |
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| item_10002_source_id_9 | ||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 18805892 | |||||||||||||||||
| 出版タイプ | ||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||
