| Item type |
紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2025-11-05 |
| タイトル |
|
|
タイトル |
Activation models of Hedgehog signaling in cancer |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 著者 |
Yurina, WAKABAYASHI
Yuexin, DING
Yoshiki, SATO
Tsuyoshi, SHIMO
|
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Hedgehog |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
cancer |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The Hedgehog (Hh) signaling pathway is a highly conserved developmental system that plays a pivotal role in tissue patterning, cellular proliferation, and differentiation. Beyond embryogenesis, Hh signaling remains crucial for adult tissue homeostasis and stem cell maintenance. Dysregulation of this pathway has been implicated in the development and progression of various human cancers. Hh pathway activation not only drives tumor cell proliferation and survival but also modulates the tumor microenvironment (TME), affecting immune regulation, angiogenesis, and bone metabolism. This mini−review aims to categorize and analyze the mechanistic diversity of Hh pathway activation in cancer, highlighting its biological significance and therapeutic implications. Recent studies have classified Hh activation mechanisms in cancer into four distinct models : ligand−independent, autocrine ligand−dependent, paracrine ligand−dependent, and reverse paracrine ligand−dependent. Ligand−independent tumors, such as basal cell carcinoma and medulloblastoma, are characterized by mutations in core Hh components like PTCH1 and SMO. Autocrine activation involves tumor−derived Hh ligands stimulating their own receptors, while paracrine activation features tumor−secreted ligands acting on surrounding stromal cells to promote tumor progression. Conversely, in reverse paracrine activation, TME cells supply Hh ligands that activate tumor cells. Understanding these diverse activation models is crucial for designing precision therapies targeting the Hh pathway. This review highlights recent advances in Hh signaling research, discusses the clinical relevance of these four activation models, and explores future prospects for targeting the Hh pathway in oncology. These mechanistic insights not only deepen our understanding of Hh pathway biology but also inform the development of context−specific therapeutic strategies, including combination approaches that integrate immune and metabolic modulation within the tumor microenvironment. |
|
言語 |
en |
| bibliographic_information |
ja : 北海道医療大学歯学雑誌
en : The Dental Journal of Health Sciences University of Hokkaido
巻 44,
号 1,
p. 37-41,
発行日 2025-06-30
|
| item_10002_source_id_9 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
18805892 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
Activation models of Hedgehog signaling in cancer (2.2 MB)
