@article{oai:hsuh.repo.nii.ac.jp:00006690,
 author = {武田, 正子},
 issue = {1},
 journal = {東日本歯学雑誌},
 month = {Dec},
 note = {P(論文), Tast bud cells of mammals were classified into four types : type I, II and III cells extending from the basement membrane to the taste pore, and basal (type IV ) cells located in the basal part. Type I cells contained dense granules in the apical cytoplasm and secreted them into pores. Type II cells contained numerous vesicles, vacuoles and smooth endoplasmic reticulum throughout the cytoplasm, although their function is unknown. Type III (gustatory or receptor) cells were characterized by the presence of afferent synaptic contacts with the nerve terminals, and of large dense-cored vesicles (80-100 nm in diameter) scattered throughout the cytoplasm. Basal cells are considered to be the stem cells which differentiate into each type of cell, I, II and IIl. Fluorescence histochemistry and light microscopic autoradiography revealed that some of taste bud cells in the mouse were capable of taking up monoamine precursors (5-HTP or L-.DOPA). By electron microscopic autoradiography, it was shown that type III was the only type of taste bud cells to incorporate exogenous ^3H-5-HTP. In addition, the ultrastructural changes were observed in the type III cells after administration of 5-HTP. Small dense-cored vesicles (30-60nm) appeared throughout the cytoplasm and accumulated especially at the presynaptic membranes of afferent synapses. The electron densities of large dense-cored vesicles (80-100nm) became more dense as compared with untreated mice. The results suggest that type III cells take up monoamine precursors and convert them to monoamines. The small and large dense-cored vesicles in the type III cells are believed capable of storing and releasing monoamines which act as neurotransmitters from the gustatory cells to the nerves.},
 pages = {1--17},
 title = {<総説>味蕾の電子顕微鏡的研究},
 volume = {1},
 year = {1982}
}