@article{oai:hsuh.repo.nii.ac.jp:00006692,
 author = {中村, 治雄 and 倉橋, 昌司 and 吉田, 昌江 and 猪股, 孝四郎},
 issue = {1},
 journal = {東日本歯学雑誌},
 month = {Dec},
 note = {P(論文), The activity of hepatic 3-hydroxy-3-methylglutaryl-CoA(HMG-CoA) reductase and 7α-hydroxylase, which are the enzymes controlling the rate of hepatic synthesis respe-ctively, in the cholesterol and bile acids were studied in mice receiving ursodesoxycholic acid (0.5% of the diet) for 10days and in the microsomal fraction containing 10-4M ursodesoxycholic acid in vitro. Both the activities of HMG-CoA reductase and cholesterol 7α-hydroxylase were reduced in vivo and in vitro.On the basis these findings, it is suggested that the decreased rate of cholesterol synthesis and cholesterol degradation to bile acid may play a significant role in the elimination of cholesterol in the serum and liver after ursodesoxycholic acid feeding.},
 pages = {39--43},
 title = {<原著>ウルソデスオキシコール酸の肝3-hydroxy-3-methylglutaryl coenzyme A reductaseと肝コレステロール7α-hydroxylase活性におよぼす作用},
 volume = {1},
 year = {1982}
}