{"created":"2023-05-15T11:30:49.164913+00:00","id":6692,"links":{},"metadata":{"_buckets":{"deposit":"5b86f92c-977d-4a12-9f2c-17012dbbc3c2"},"_deposit":{"created_by":17,"id":"6692","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"6692"},"status":"published"},"_oai":{"id":"oai:hsuh.repo.nii.ac.jp:00006692","sets":["89:516"]},"author_link":["20391","34502","34503","34504"],"item_1693191265938":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_2_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1982-12-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"43","bibliographicPageStart":"39","bibliographicVolumeNumber":"1","bibliographic_titles":[{"bibliographic_title":"東日本歯学雑誌","bibliographic_titleLang":"ja"}]}]},"item_2_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中村, 治雄","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"20391","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"倉橋, 昌司","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"34502","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田, 昌江","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"34503","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"猪股, 孝四郎","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"34504","nameIdentifierScheme":"WEKO"}]}]},"item_2_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_2_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"The activity of hepatic 3-hydroxy-3-methylglutaryl-CoA(HMG-CoA) reductase and 7α-hydroxylase, which are the enzymes controlling the rate of hepatic synthesis respe-ctively, in the cholesterol and bile acids were studied in mice receiving ursodesoxycholic acid (0.5% of the diet) for 10days and in the microsomal fraction containing 10-4M ursodesoxycholic acid in vitro. Both the activities of HMG-CoA reductase and cholesterol 7α-hydroxylase were reduced in vivo and in vitro.On the basis these findings, it is suggested that the decreased rate of cholesterol synthesis and cholesterol degradation to bile acid may play a significant role in the elimination of cholesterol in the serum and liver after ursodesoxycholic acid feeding.","subitem_description_type":"Other"}]},"item_2_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN0008135X","subitem_source_identifier_type":"NCID"}]},"item_2_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Oral Physiology, School of Dentistry,HIGASHI-NIPPON-GAKUEN UNIVERSITY"}]},"item_2_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"東日本学園大学歯学部口腔生理学講座"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"1982-12-31"}],"displaytype":"detail","filename":"KJ00000094303.pdf","filesize":[{"value":"300.0 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"<原著>ウルソデスオキシコール酸の肝3-hydroxy-3-methylglutaryl coenzyme A reductaseと肝コレステロール7α-hydroxylase活性におよぼす作用","objectType":"fulltext","url":"https://hsuh.repo.nii.ac.jp/record/6692/files/KJ00000094303.pdf"},"version_id":"5c55c4bc-c11a-4198-b14c-f3c4fdfa8ab8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Ursodesoxycholic acid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"HMG-CoA reductase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cholesterol 7α-hydroxylase","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"<原著>ウルソデスオキシコール酸の肝3-hydroxy-3-methylglutaryl coenzyme A reductaseと肝コレステロール7α-hydroxylase活性におよぼす作用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"<原著>ウルソデスオキシコール酸の肝3-hydroxy-3-methylglutaryl coenzyme A reductaseと肝コレステロール7α-hydroxylase活性におよぼす作用","subitem_title_language":"ja"},{"subitem_title":"<ORIGINAL ARTICLE>Effects of Ursodesoxycholic Acid on 3-hydroxy-3-methylglutaryl Coenzyme A Reductase and Cholesterol 7α-hydroxylase Activity in Mice Liver Microsomes","subitem_title_language":"en"}]},"item_type_id":"2","owner":"17","path":["516"],"pubdate":{"attribute_name":"PubDate","attribute_value":"1982-12-31"},"publish_date":"1982-12-31","publish_status":"0","recid":"6692","relation_version_is_last":true,"title":["<原著>ウルソデスオキシコール酸の肝3-hydroxy-3-methylglutaryl coenzyme A reductaseと肝コレステロール7α-hydroxylase活性におよぼす作用"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-12-21T06:40:53.366138+00:00"}