{"created":"2023-05-15T11:31:14.362952+00:00","id":7284,"links":{},"metadata":{"_buckets":{"deposit":"c4830f21-a5ee-4a05-9a53-bb52534851d9"},"_deposit":{"created_by":17,"id":"7284","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"7284"},"status":"published"},"_oai":{"id":"oai:hsuh.repo.nii.ac.jp:00007284","sets":["89:539"]},"author_link":["22142","35052","35053","35054","35055","35056","35057","35058","35059","35060"],"item_1693191265938":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_2_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1986-12-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"151","bibliographicPageStart":"143","bibliographicVolumeNumber":"5","bibliographic_titles":[{"bibliographic_title":"東日本歯学雑誌","bibliographic_titleLang":"ja"}]}]},"item_2_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"賀来, 亨","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"22142","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中出, 修","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"35052","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉川, 泰子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"35053","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"八重樫, 和秀","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"35054","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大内, 知之","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"35055","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"舘山, 美樹","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"35056","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"阿部, 英二","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"35057","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菅野, 秀俊","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"35058","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"江戸, 稔","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"35059","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"奥山, 富三","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"35060","nameIdentifierScheme":"WEKO"}]}]},"item_2_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_2_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"This study describes the kinetics of induction and reinduction of GGT-stained cell populations (GGT-positive foci) induced in hamster cheek pouch epithelium by experimental protocols. The animals were divided into five groups and Groups 1,2,3 , and 4 were treated with biweekly topical applications of DMBA for 1,2,3 , and 5 weeks respectively (Phase 1 ). Then animals left untreated for 10 weeks (Phase 2 ), followed by three topical applications of DMBA a Monday-Friday-Monday sequence (Phase 3). Group 5 received the Phase 3 treatment only. GGT stained cells appeared rapidly in the epithelium of hamster cheek pouches treated by biweekly applications of DMBA. GGT-positive foci was only rarely detected in animals left untreated for the additional 10 weeks after completion of Phase 1. However, 3 applications of DMBA (Phase 3) resulted in the rapid formation of numerous GGT-positive foci in animals treated lOweeks previously with applications of DMBA (Phase 1 ) in all experimental groups. The Phase 3 treatment alone induced only 130 ± 50 GGT-positive foci per 10cm^2. The Resumption of the DMBA treatment appeared to reinduce GGT in occulted (unstained) foci which were present during the 10 weeks. A comparison of the size distribution of the foci at the completion of each treatment phase also suggests that the occulted (unstained) foci do not undergo further lateral growth during the 10-week treatment interval. The results suggest that a brief series of 3 DMBA applications reinduced GGT histochemical activity in occulted (unstained) foci which had lost enzyme activity. The expression of GGT in the majority of the foci is a transient metabolic phenomenon associated with DMBA exposure, whereas the induction of the foci is a persistent and possibly permanent consequence of prior DMBA exposure.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_2_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN0008135X","subitem_source_identifier_type":"NCID"}]},"item_2_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Oral Pathology, School of Dentistry HIGASHI-NIPPON-GAKUEN UNIVERSITY"},{"subitem_text_language":"en"}]},"item_2_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"東日本学園大学歯学部口腔病理学講座"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"1986-12-31"}],"displaytype":"detail","filename":"KJ00000094552.pdf","filesize":[{"value":"467.4 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"<原著>ハムスター頬嚢におけるDMBA再塗布によるGGT陽性巣の再誘導について","objectType":"fulltext","url":"https://hsuh.repo.nii.ac.jp/record/7284/files/KJ00000094552.pdf"},"version_id":"fa2d7e17-92be-4c8c-8df2-f31bc038613e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"DMBA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"GGT-positive foci","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"reinduction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cheek pouch","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"<原著>ハムスター頬嚢におけるDMBA再塗布によるGGT陽性巣の再誘導について","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"<原著>ハムスター頬嚢におけるDMBA再塗布によるGGT陽性巣の再誘導について","subitem_title_language":"ja"},{"subitem_title":"<ORIGINAL ARTICLE>Reinduction of GGT-positive Foci in the Hamster Cheek Pouch by a Resumption of DMBA Application","subitem_title_language":"en"}]},"item_type_id":"2","owner":"17","path":["539"],"pubdate":{"attribute_name":"PubDate","attribute_value":"1986-12-31"},"publish_date":"1986-12-31","publish_status":"0","recid":"7284","relation_version_is_last":true,"title":["<原著>ハムスター頬嚢におけるDMBA再塗布によるGGT陽性巣の再誘導について"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-12-26T03:01:18.785249+00:00"}