{"created":"2023-05-15T11:31:20.834791+00:00","id":7433,"links":{},"metadata":{"_buckets":{"deposit":"1f08d83f-cb99-43ba-8526-28080bdd7c99"},"_deposit":{"created_by":17,"id":"7433","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"7433"},"status":"published"},"_oai":{"id":"oai:hsuh.repo.nii.ac.jp:00007433","sets":["89:543"]},"author_link":["22365","35506","35507","35508"],"item_1693191265938":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_2_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1988-12-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"72","bibliographicPageStart":"67","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"東日本歯学雑誌","bibliographic_titleLang":"ja"}]}]},"item_2_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"相良, りか子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"22365","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松井, 聡子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"35506","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"東城, 庸介","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"35507","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本, 仁人","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"35508","nameIdentifierScheme":"WEKO"}]}]},"item_2_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_2_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"The effects of Ca^<2+> and EGTA on rat parotid amylase secretion and cyclic AMP accumulation were investigated in vitro using a dispersed acinar cell preparation. Amylase secretion induced by isoproterenol and dibutyryl cyclic AMP was significantly enhanced by pre-treatment (30min) with more than 50μM Ca^<2+>. Depletion of intracellular Ca^<2+> by pre-treatment with 2mM EGTA reduced the amylase secretion, although the pre-treatment was unable to completely block the secretion. The pre-treatment with Ca^<2+> and EGTA did not alter the rise in cellular cyclic AMP induced by isoproterenol. These results suggest that intracellular Ca^<2+> is necessary to elicit the maximum amylase secretion and that Ca^<2+> may be involved in the exocytosis of parotid amylase at steps distal from the cyclic AMP metabolism.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_2_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN0008135X","subitem_source_identifier_type":"NCID"}]},"item_2_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Dental Pharmacology, School of Dentistry, HIGASHI-NIPPON-GAKUEN UNIVERSITY"}]},"item_2_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"東日本学園大学歯学部歯科薬理学講座"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"1988-12-31"}],"displaytype":"detail","filename":"KJ00000094702.pdf","filesize":[{"value":"455.8 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"<原著>ラット耳下腺細胞のアミラーゼ分泌反応とサイクリックAMP生成に対するCa^<2+>およびEGTAの効果","objectType":"fulltext","url":"https://hsuh.repo.nii.ac.jp/record/7433/files/KJ00000094702.pdf"},"version_id":"658b0f3b-936e-455a-9a12-dcffce8402ab"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"parotid glands","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"amylase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Ca","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"EGTA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cyclic AMP","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"<原著>ラット耳下腺細胞のアミラーゼ分泌反応とサイクリックAMP生成に対するCa^<2+>およびEGTAの効果","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"<原著>ラット耳下腺細胞のアミラーゼ分泌反応とサイクリックAMP生成に対するCa^<2+>およびEGTAの効果","subitem_title_language":"ja"},{"subitem_title":"<ORIGINAL ARTICLE>Effect of Ca^<2+> and EGTA on amylase secretion and cyclic AMP accumulation in rat parotid cells","subitem_title_language":"en"}]},"item_type_id":"2","owner":"17","path":["543"],"pubdate":{"attribute_name":"PubDate","attribute_value":"1988-12-31"},"publish_date":"1988-12-31","publish_status":"0","recid":"7433","relation_version_is_last":true,"title":["<原著>ラット耳下腺細胞のアミラーゼ分泌反応とサイクリックAMP生成に対するCa^<2+>およびEGTAの効果"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-12-26T07:33:55.568814+00:00"}