{"created":"2023-05-15T11:31:20.877676+00:00","id":7434,"links":{},"metadata":{"_buckets":{"deposit":"8f680a2f-4536-4966-a3bf-382daf9a2dfb"},"_deposit":{"created_by":17,"id":"7434","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"7434"},"status":"published"},"_oai":{"id":"oai:hsuh.repo.nii.ac.jp:00007434","sets":["89:543"]},"author_link":["22368","22370","35509","35510","35511"],"item_1693191265938":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_2_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1988-12-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"81","bibliographicPageStart":"73","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"東日本歯学雑誌","bibliographic_titleLang":"ja"}]}]},"item_2_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"渡部, 茂","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"22368","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中村, 俊雄","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"五十嵐, 清治","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"市田, 篤郎","creatorNameLang":"ja"}]}]},"item_2_creator_8":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"WATANABE, Shigeru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"22370","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"NAKAMURA, Toshio","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"35509","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"IGARASHI, Seiji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"35510","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ICHIDA, Tokuro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"35511","nameIdentifierScheme":"WEKO"}]}]},"item_2_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_2_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"抗てんかん剤の長期服用は, 歯肉増殖を誘発したり, 体内の無機質, ビタミンD代謝に障害を及ぼすことが一般によく知られている。今回我々は, phenytoin(PHT)の唾液中成分に及ぼす影響について検討を行った。施設にて長期間PHTを服用している36人の重症心身障害児より, 血漿と混合唾液を採取した血漿の一部は超濾過し, ELISAにてPHT濃度を測定した。血中および混合唾液中の成分を36人の健康人と比較した結果, 唾液中のカルシウムと無機リンは, コントロール群に比較し, 著しく高い値を示した。一方, 安静時唾液, PH,その他の成分については差は認められなかった。血漿中カルシウムと無機リンの比較では, 両グループに差はみられなかったが, カルシウムとリンの積の比較では, PHT投与群の方が低い値を示した。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_2_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"It is well recognized that chronic anticonvulsant drug therapy produces significant disorders of mineral and vitamin D metabolism, as well as possible gingival enlargement. The purpose of this study was to evaluate the effect of Phenytoin (PHT) on the main components of saliva. Blood plasma and whole saliva were collected from 36 severely handicapped patients who had been administered PHT for a long period of time in an asylum and from 36 healthy controls. One portion of the blood plasma from the patients was ultrafiltered and the PHT concentration was determined by ELISA. The concentrations of calcium (Ca) and inorganic phosphate (Pi) were significantly higher (p<0.001) in whole saliva from the PHT group, while no significant changes in unstimulated flow rate, pH, and the other components were found. There were no group differences in the mean plasma concentrations of Ca and Pi, but the value of the product of these two was lower in the PHT group than in the control group (p<0.02).","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_2_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN0008135X","subitem_source_identifier_type":"NCID"}]},"item_2_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Pedodontics, School of Dentistry HIGASHI-NIPPON-GAKUEN UNIVERSITY/Department of Oral Biochemistry, School of Dentistry HIGASHI-NIPPON-GAKUEN UNIVERSITY"}]},"item_2_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"東日本学園大学歯学部小児歯科学講座/東日本学園大学歯学部口腔生化学講座"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"1988-12-31"}],"displaytype":"detail","filename":"KJ00000094703.pdf","filesize":[{"value":"532.7 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"<Original>Effect of Phenytoin on the Salivary Composition in Handicapped Patients","objectType":"fulltext","url":"https://hsuh.repo.nii.ac.jp/record/7434/files/KJ00000094703.pdf"},"version_id":"402646a1-c76d-4a57-9d07-9c749f456f79"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Phenytoin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"salivary calcium","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"salivary phosphate","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"<Original>Effect of Phenytoin on the Salivary Composition in Handicapped Patients","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"<Original>Effect of Phenytoin on the Salivary Composition in Handicapped Patients","subitem_title_language":"en"},{"subitem_title":"<原著>Phenytoinの唾液成分に及ぼす影響について","subitem_title_language":"ja"}]},"item_type_id":"2","owner":"17","path":["543"],"pubdate":{"attribute_name":"PubDate","attribute_value":"1988-12-31"},"publish_date":"1988-12-31","publish_status":"0","recid":"7434","relation_version_is_last":true,"title":["<Original>Effect of Phenytoin on the Salivary Composition in Handicapped Patients"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-12-26T07:33:57.711330+00:00"}