{"created":"2023-05-15T11:31:49.249107+00:00","id":8059,"links":{},"metadata":{"_buckets":{"deposit":"20883a7a-3208-4673-a7b8-21effe223e92"},"_deposit":{"created_by":17,"id":"8059","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"8059"},"status":"published"},"_oai":{"id":"oai:hsuh.repo.nii.ac.jp:00008059","sets":["89:556"]},"author_link":["24417","36606","36607","36608"],"item_1693191265938":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"VoR"}]},"item_2_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1995-06-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"12","bibliographicPageStart":"1","bibliographicVolumeNumber":"14","bibliographic_titles":[{"bibliographic_title":"東日本歯学雑誌","bibliographic_titleLang":"ja"}]}]},"item_2_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"安河内, 太郎","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"24417","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐藤, 雅寛男","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"36606","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"家子, 正祐","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"36607","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"沢田, 賢一","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"36608","nameIdentifierScheme":"WEKO"}]}]},"item_2_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_2_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"Fibrinolytic promotion factors are regulated by two processes: one is dependent on a complex formation between these factors and α_2-macrogulobulin (α_2M), the other does not depend on complex formation. 1. With the complex formation: Here, the important roles of α_2M are specially referred to. In addition to the role of α_2M as a protease inhibitor, a further role has been proposed for α_2M as a binding protein of four major classes of proteases (serine, cysteine, aspartic and metalloproteases) and non-proteolytic amines, peptides, and proteins. A protease, as tissue plasminogen activator (tPA), trapped by α_2M suffers an apparent decrease in activity compared with free tPA, but the activity is preserved and protected from the specific inhibitor, as plasminogen activator inhibitor-1 (PAI-1). Plasmin trapped by α_2M, however, is not able to dissolve fibrin. The reason for this phenomenon appears to be that the fibrin molecule is too big to be attacked by the active center of plasmin in α_2M, although the plasmin still reserves the activity. The binding of α_2M to methyl-amine or protease activates α_2M and takes part in a conformational change. The α_2M protese complex, however, exposes the recognition site of the α_2M to the specific receptor and is rapidly removed from circulating blood. The α_2M specific receptor (α_2MR) is a identical with low density lipoprotein (LDL) receptor-related protein (LRP) : LRP/α_2MR. In addition, α_2M is an acute phase reactant and seems to trap various enzymes and products induced from inflammatory processes. Therefore, the most important role of α_2M is considered to be as a scavenger in circulating blood. 2. The second process of regulation of fibrinolytic promotion factors directly depends on LRP/α_2MR: Plasmiongen activator (PA) such as tPA or urokinase (uPA) forms a complex with PA-1. This complex is trapped by LRP/α_2MR, which is exprssed on the cell surface of the liver, and is removed rapidly from circulating blood. The tPA, which does not form a complex with PAI-1, trapped by LRP/α_2MR, is removed rapidly from circulating blood. The tPA, which does not form a complex with PAI-1, binds with PAI-1 already bound with vitronectin on the cell surface of liver. After the binding between tPA and PAI-1-vitronectin, the tPA-PAI-1 complex separates the vitronectin and the complex is also trapped by LRP/α_2MR.The regulation of Pro-uPA proceeds as follows: pro-uPA binds uPA receptor (uPAR), PAI-1 binds the pro-uPA and forms a uPAR-pro-uPA-PAI-1 complex. The complex binds LRP/α_2MR and is internalized in liver cells.","subitem_description_type":"Other"}]},"item_2_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN0008135X","subitem_source_identifier_type":"NCID"}]},"item_2_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Internal Medicine, School of Dentistry, Health Scienses University of Hokkaido/Second Department of Internal Medicine, Hokkaido University School of Medicine"}]},"item_2_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"北海道医療大学歯学部/北海道大学医学部"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"1995-06-30"}],"displaytype":"detail","filename":"KJ00000095329.pdf","filesize":[{"value":"905.2 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"<総説>線溶系の調節機構 : とくにα_2-Macroglobulinとその受容体について","objectType":"fulltext","url":"https://hsuh.repo.nii.ac.jp/record/8059/files/KJ00000095329.pdf"},"version_id":"1cc47418-5ca6-494a-a0eb-0785c8b34a54"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Fibrinolytic Factors","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"α_2M","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"LRP/α_2MR","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"<総説>線溶系の調節機構 : とくにα_2-Macroglobulinとその受容体について","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"<総説>線溶系の調節機構 : とくにα_2-Macroglobulinとその受容体について","subitem_title_language":"ja"},{"subitem_title":"<REVIEW>Regulation of Fibrinolytic Factors : With Special Reference to α_2-Macroglobulin and it's Receptor","subitem_title_language":"en"}]},"item_type_id":"2","owner":"17","path":["556"],"pubdate":{"attribute_name":"PubDate","attribute_value":"1995-06-30"},"publish_date":"1995-06-30","publish_status":"0","recid":"8059","relation_version_is_last":true,"title":["<総説>線溶系の調節機構 : とくにα_2-Macroglobulinとその受容体について"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2024-02-08T07:30:27.124448+00:00"}