{"created":"2023-05-15T11:32:06.412331+00:00","id":8425,"links":{},"metadata":{"_buckets":{"deposit":"f63ebbe0-f523-4e0f-893c-b52814dbae49"},"_deposit":{"created_by":17,"id":"8425","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"8425"},"status":"published"},"_oai":{"id":"oai:hsuh.repo.nii.ac.jp:00008425","sets":["89:564"]},"author_link":["25528"],"item_2_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999-06-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"140","bibliographicPageStart":"117","bibliographicVolumeNumber":"18","bibliographic_titles":[{"bibliographic_title":"東日本歯学雑誌","bibliographic_titleLang":"ja"}]}]},"item_2_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"神田, 秀治","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"25528","nameIdentifierScheme":"WEKO"}]}]},"item_2_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_2_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"This study examined whether local anesthetics react with superoxide (O・/2) radicals and generate other oxygen radicals. Lidocaine, mepibacaine, prilocaine, and dibucaine were used as amido type anesthetics ; procaine, and tetracaine as ester type anesthetics ; and epinephrine and ephedrine as epinephrine-like substances. A hypoxanthine-xanthine oxidase (HPX-XOD) reaction system was employed as the O・/2 generator. Detection and measurements were carried out with the ESR spin trapping method. When amido type anesthetics were added with epinephrine, alkoxyl (RO・) and hydroxyl (HO・) radical generation was confirmed, but there was no RO・ and HO・ generation with ephedrine. With ester type anesthetics with epinephrine, there was no RO・ generation. The signal intensities of RO・ and HO・ were dependent on the concentration of anesthetics and epinephrine. These results show that RO・ and HO・ generation by local anesthetics occur only where amido type anesthetics, cathecols, and (O・/2) are present.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_2_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN0008135X","subitem_source_identifier_type":"NCID"}]},"item_2_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Dental Radiology, school of Dentistry, Health Sciences University of Hokkaido"}]},"item_2_text_2":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"原著"}]},"item_2_text_3":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"ORIGINAL"}]},"item_2_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"北海道医療大学歯学部歯科放射線学講座"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"1999-06-30"}],"displaytype":"detail","filename":"KJ00003417157.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"酸素ラジカル発生系に及ぼす歯科用麻酔薬の影響","objectType":"fulltext","url":"https://hsuh.repo.nii.ac.jp/record/8425/files/KJ00003417157.pdf"},"version_id":"acb9650a-7088-4f9d-9ff9-dbb56147be17"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Local anesthetic","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"alkoxyl radical","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hydroxyl radical","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"epinephrine","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"酸素ラジカル発生系に及ぼす歯科用麻酔薬の影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"酸素ラジカル発生系に及ぼす歯科用麻酔薬の影響","subitem_title_language":"ja"},{"subitem_title":"Influence of local anesthetics upon oxygen radical generation","subitem_title_language":"en"}]},"item_type_id":"2","owner":"17","path":["564"],"pubdate":{"attribute_name":"PubDate","attribute_value":"1999-06-30"},"publish_date":"1999-06-30","publish_status":"0","recid":"8425","relation_version_is_last":true,"title":["酸素ラジカル発生系に及ぼす歯科用麻酔薬の影響"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2024-02-28T00:45:53.664381+00:00"}