{"created":"2023-05-15T11:32:06.453942+00:00","id":8426,"links":{},"metadata":{"_buckets":{"deposit":"12f5b5e3-e351-49bc-ab9e-62914a13d481"},"_deposit":{"created_by":17,"id":"8426","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"8426"},"status":"published"},"_oai":{"id":"oai:hsuh.repo.nii.ac.jp:00008426","sets":["89:564"]},"author_link":["25531","25532","25533","25534","25535","25536","25537"],"item_2_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999-06-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"146","bibliographicPageStart":"141","bibliographicVolumeNumber":"18","bibliographic_titles":[{"bibliographic_title":"東日本歯学雑誌","bibliographic_titleLang":"ja"}]}]},"item_2_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"國分, 正廣","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"25531","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小田, 和明","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"25532","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河合, 拓郎","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"25533","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大桶, 華子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"25534","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤, 元康","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"25535","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"工藤, 勝","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"25536","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"新家, 昇","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"25537","nameIdentifierScheme":"WEKO"}]}]},"item_2_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_2_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"The local anesthetic effects of calcium antagonists (diltiazem, verapamil, and nicardipine) on extracted rabbit vagus nerve (Fig. 1) and their binding ability to the phospholipid membrane model were examined by ^1H-NMR spectroscopy. Effective concentrations of these drugs for vagus nerve blockage were examined with 12～14V electrical stimuli. The minimum effective concentration of calcium antagonist which completely blocked the compound action potential was 0.5mM for diltiazem, and 0.2mM for verapamil. Nicardipine did not show any conduction blocking effect at 1.0mM. Local anesthetic effects of ditiazem and verapamil were characterized by a slower onset (over 20 min) and longer duration (over 30 min) compared with lidocaine (Table 1). The local anesthetic effects of dilitiazem and verapamil may be due to the SA and AV nodal blocking effect and reductions in the ventricular rate by these drugs. However, in the SA and AV nodes, depolarization is largely dependent on the movement of Ca^<2+> through the slow channel. The results of ^1H-NMR spectroscopy indicated that poor electrostatic binding with the phospholipid membrane occured only with diltiazem (Fig. 2). Local anesthetic effects of calcium antagonists may not be based on electrostatic binding with the nerve membrane as in the case of local anesthetics.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_2_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN0008135X","subitem_source_identifier_type":"NCID"}]},"item_2_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Dental Anesthesiology, Faculty of Dentistry, Health Sciences University of Hokkaido"},{"subitem_text_language":"en","subitem_text_value":"Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido"}]},"item_2_text_2":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"原著"}]},"item_2_text_3":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"ORIGINAL"}]},"item_2_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"北海道医療大学歯学部歯科麻酔学講座"},{"subitem_text_language":"ja","subitem_text_value":"北海道医療大学薬学部化学講座"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"1999-06-30"}],"displaytype":"detail","filename":"KJ00003417158.pdf","filesize":[{"value":"402.3 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"カルシウム拮抗薬のもつ局所麻酔様作用","objectType":"fulltext","url":"https://hsuh.repo.nii.ac.jp/record/8426/files/KJ00003417158.pdf"},"version_id":"5f0157f1-a8c7-43b9-b640-dadc22952115"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Calsium Antagonist","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Local Anesthetic Action","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"NMR-Spectroscopy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Nerver Blockage","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"カルシウム拮抗薬のもつ局所麻酔様作用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"カルシウム拮抗薬のもつ局所麻酔様作用","subitem_title_language":"ja"},{"subitem_title":"Local Anesthetic Effects of Calcium Antagonists (Diltiazem, Verapamil, and Nicardipine) on Extracted Rabbit Vagus Nerve","subitem_title_language":"en"}]},"item_type_id":"2","owner":"17","path":["564"],"pubdate":{"attribute_name":"PubDate","attribute_value":"1999-06-30"},"publish_date":"1999-06-30","publish_status":"0","recid":"8426","relation_version_is_last":true,"title":["カルシウム拮抗薬のもつ局所麻酔様作用"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2024-02-28T00:45:56.307916+00:00"}