@article{oai:hsuh.repo.nii.ac.jp:00008500, author = {竹林, 義人}, issue = {2}, journal = {東日本歯学雑誌}, month = {Dec}, note = {P(論文), This study examined the effect of ascorbic acid (AsA) which acts as a hydroxyl radical scavenger when exposed to X-rays The X-ray irradiation produced hydroxyl radicals in the medium and the amount of hydroxyl radicals increased markedly with increases m the X-ray dose Apoptotic changes of HL60 cells were observed with the irradiation When the concentration of AsA was above 0 ImM, the AsA scavenged the hydroxyl radicals which were formed in the medium However, 1mM AsA generated ascorbate radicals and induced apoptosis of HL60 cells without radiation With O.lmM AsA, hydroxyl radicals were scavenged and did not induce cell death However, DNA fragmentation of HL60 cells with X-ray irradiation in 0 1mM AsA was observed to be faster than in the non-treated medium These findings suggest that AsA did not influence the effect of radiation}, pages = {325--336}, title = {<原著>HL60(ヒト前骨髄性白血病由来細胞)に対するアスコルビン酸と放射線の影響に関する研究}, volume = {18}, year = {1999} }