{"created":"2023-05-15T11:32:09.688187+00:00","id":8502,"links":{},"metadata":{"_buckets":{"deposit":"b9d08d7c-3180-4b66-8803-c20a24f2dded"},"_deposit":{"created_by":17,"id":"8502","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"8502"},"status":"published"},"_oai":{"id":"oai:hsuh.repo.nii.ac.jp:00008502","sets":["89:565"]},"author_link":["25912"],"item_2_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999-12-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"361","bibliographicPageStart":"347","bibliographicVolumeNumber":"18","bibliographic_titles":[{"bibliographic_title":"東日本歯学雑誌","bibliographic_titleLang":"ja"}]}]},"item_2_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"北所, 弘行","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"25912","nameIdentifierScheme":"WEKO"}]}]},"item_2_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_2_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"To observe the effect of Hepatocyte growth factor/scatter factor (HGF/SF) on the invasion and metastasis of human oral squamous cell carcinoma (SCO cells, the invasive ability and internal signal transduction were examined The invasive ability of tumor cells (SAS, HSC-3,Ca9-22) was enhanced dose-dependently by HGF/SF stimulation, and C3 exoenzyme which is a specific inhibitor of Rho activation significantly reduced the invasive ability of SAS cells The HGF/SF stimulation enhanced the tyrosin phosphorylation of HGF receptors (c-Met) and focal adhesion kmase (FAK^<p125>) of SAS cells, and C3 exoenzyme completely inhibited the activation of FAK^<p125> It was observed that Rho protein located around the nuclear area translocated to the membrane area and subsequently increased in the cytolysate, following HGF/SF stimulation These results suggest that the activation of FAK^<p125> caused by phosphorylation of c-Met may enhance the HGF/SF, inducing invasive ability and that Rho protein possibly regulates the activation of FAK^<p125> through the translocation itself","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_2_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN0008135X","subitem_source_identifier_type":"NCID"}]},"item_2_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Second Department of Oral and Maxillofacial Surgery, a School of Dentistry, Health Sciences University of Hokkaido"}]},"item_2_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"北海道医療大学歯学部口腔外科学第二講座"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"1999-12-30"}],"displaytype":"detail","filename":"KJ00000095773.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"<原著>肝細胞増殖因子(HGF/SF)によるヒト口腔扁平上皮癌細胞の浸潤シグナルの検討 : 特に低分子量GTP結合蛋白質Rhoの関与について","objectType":"fulltext","url":"https://hsuh.repo.nii.ac.jp/record/8502/files/KJ00000095773.pdf"},"version_id":"80959934-013b-41d5-a935-c2744331b85e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Hepatocyte growth factor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Intraceller signal transductin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Invasion","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Small GTP binding protein","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Oral squamous cell carcinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"<原著>肝細胞増殖因子(HGF/SF)によるヒト口腔扁平上皮癌細胞の浸潤シグナルの検討 : 特に低分子量GTP結合蛋白質Rhoの関与について","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"<原著>肝細胞増殖因子(HGF/SF)によるヒト口腔扁平上皮癌細胞の浸潤シグナルの検討 : 特に低分子量GTP結合蛋白質Rhoの関与について","subitem_title_language":"ja"},{"subitem_title":"<ORIGINAL ARTICLE>Study of invasive signal transduction of human oral squamous cell carcinoma cell lines by hepatocyte growth fator/scatter factor : Especialy the relation of small GTP binding protein Rho","subitem_title_language":"en"}]},"item_type_id":"2","owner":"17","path":["565"],"pubdate":{"attribute_name":"PubDate","attribute_value":"1999-12-30"},"publish_date":"1999-12-30","publish_status":"0","recid":"8502","relation_version_is_last":true,"title":["<原著>肝細胞増殖因子(HGF/SF)によるヒト口腔扁平上皮癌細胞の浸潤シグナルの検討 : 特に低分子量GTP結合蛋白質Rhoの関与について"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2024-02-28T00:48:18.606286+00:00"}