@article{oai:hsuh.repo.nii.ac.jp:00008578,
 author = {小田,浩範 and 柴田,敏之 and 村田,勝 and 有末,眞 and 村瀬,博文 and ODA,Hironori/SHIBATA,Toshiyuki/MURATA,Masaru/ARISUE,Makoto/MURASE,Hirofumi},
 issue = {2},
 journal = {東日本歯学雑誌},
 month = {Dec},
 note = {P(論文), It is well known that hydroxyapatite (HAP), which has a high tissue affinity and superior bone conductivity, shows different characteristics depending on the sintering temperature. This study prepared single hydroxyapatite (SHAP) and coated hydroxyapatite (CHAP). The SHAP was sintered at high temperature (1250℃). The structure of CHAP was low temperature (150℃) sintered apatite coated with SHAP. The usefulness of CHAP for bone formation was examined in cylindrical bone defects (diameter : 5mm ; depth : 9mm) created in the mandible of adult dogs 2 months after extraction of the teeth (P4, M1). Calcein (8mg/kg) was injected 2 days before scarification and mandibular bone was removed at 7, 14, 30, 60, 90, and 120days. The explanted bone was fixed in 10% formaldehyde in saline and soaked in Villanueva bone stain solution. Non-demineralized coronal sections (70μm) were made and observed by fluorescence microscopy and microradiography. At 7days after implantation, bone formation occurred from the cavity surface in the CHAP group, but not in the SHAP group. At 14days, newly formed bone was observed around the HAP particles only in the CHAP group. Bone formation in the CHAP group was more rapid than in the SHAP group until 90days, though no significant differences were observed at 120days. These results suggest that CHAP particles may be useful as a filling material for bone defects in the field of oral and maxillofacial surgery.},
 pages = {159--170},
 title = {<原著>コーティング・ハイドロキシアパタイト顆粒の骨形成能に関する実験的研究},
 volume = {19},
 year = {2000}
}