@article{oai:hsuh.repo.nii.ac.jp:00008711,
 author = {國安, 宏哉 and 広瀬, 由紀人 and 賀来, 亨 and 金子, 昌幸 and 田隈, 泰信},
 issue = {1},
 journal = {東日本歯学雑誌},
 month = {Jun},
 note = {P(論文), This study assessed the efficacy and technical feasibility of inducing bone formation in an animal model of maxillary sinus floor augmentation using β-tricalcium phosphate (β-TCP) matrix with recombinant human growth differentiation factor 5 (rhGDF-5). The study used adult beagle dogs weighing 10 to 12 kg. The composite of the β-TCP matrix with rhGDF-5 (rhGDF-5/β-TCP) is made of approximately 300 micro-meter β-TCP particles and rhGDF-5 which contained 500 micro-gram per gram of β-TCP particles. Exposure of the frontal sinus was carried out bilaterally, with one sinus receiving 2 grams of the rhGDF-5/β-TCP implant and the other receiving 2 grams of β-TCP particles alone (control) . The frontal sinuses were excised 1, 2, 4, 8, 12, and 16 weeks after surgery and the bone formation in response to the rhGDF-5/β-TCP implant was evaluated histologically. At 2 weeks of postimplantation in the site implanted with rhGDF-5/β-TCP, new cancellous bone appeared at localized sites on the original bone surface. In contrast, there was no evidence of new bone formation at the control implant site. At 8 weeks, interconnected trabecular structure and bone marrow were found within the sinus of the rhGDF-5/β-TCP implants. Cartilage was not found in any region and residues of carrier β-TCP were seen in the middle area. At the site of the received controlimplants, the bulk of implanted β-TCP particles remained within the sinus. At 12 weeks, the large new trabecular bone extended to the original bone surfaces in the center of the implant site of the rhGDF-5/β-TCP implants. At the control site, little new cancellous bone was formed in the middle area. At 16 weeks, rhGDF-5/β-TCP implants increased new bone formation with the lapse of time and β-TCP particles were almost all absorbed. The present study showed that rhGDF-5 coated on β-TCP matrix successfully it maybe induced bone formation in the floor of the frontal sinus in a suitable animal model. Therfore, we conclude that the β-TCP matrix with rhGDF-5 could provide an acceptable biomaterial for maxillary sinus floor augmentation.},
 pages = {11--23},
 title = {<原著>Growth Differentiation Factor-5/β-TCP複合体によるビーグル犬前頭洞内骨形成に関する実験的研究},
 volume = {21},
 year = {2002}
}