{"created":"2023-05-15T11:32:18.679784+00:00","id":8711,"links":{},"metadata":{"_buckets":{"deposit":"2ea02bb9-8732-4b3b-b9e2-5d17837c4d7b"},"_deposit":{"created_by":17,"id":"8711","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"8711"},"status":"published"},"_oai":{"id":"oai:hsuh.repo.nii.ac.jp:00008711","sets":["89:570"]},"author_link":["26324","37275","37276","37277","37278"],"item_2_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-06-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"23","bibliographicPageStart":"11","bibliographicVolumeNumber":"21","bibliographic_titles":[{"bibliographic_title":"東日本歯学雑誌","bibliographic_titleLang":"ja"}]}]},"item_2_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"國安, 宏哉","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"26324","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"広瀬, 由紀人","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"37275","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"賀来, 亨","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"37276","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"金子, 昌幸","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"37277","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田隈, 泰信","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"37278","nameIdentifierScheme":"WEKO"}]}]},"item_2_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_2_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"This study assessed the efficacy and technical feasibility of inducing bone formation in an animal model of maxillary sinus floor augmentation using β-tricalcium phosphate (β-TCP) matrix with recombinant human growth differentiation factor 5 (rhGDF-5). The study used adult beagle dogs weighing 10 to 12 kg. The composite of the β-TCP matrix with rhGDF-5 (rhGDF-5/β-TCP) is made of approximately 300 micro-meter β-TCP particles and rhGDF-5 which contained 500 micro-gram per gram of β-TCP particles. Exposure of the frontal sinus was carried out bilaterally, with one sinus receiving 2 grams of the rhGDF-5/β-TCP implant and the other receiving 2 grams of β-TCP particles alone (control) . The frontal sinuses were excised 1, 2, 4, 8, 12, and 16 weeks after surgery and the bone formation in response to the rhGDF-5/β-TCP implant was evaluated histologically. At 2 weeks of postimplantation in the site implanted with rhGDF-5/β-TCP, new cancellous bone appeared at localized sites on the original bone surface. In contrast, there was no evidence of new bone formation at the control implant site. At 8 weeks, interconnected trabecular structure and bone marrow were found within the sinus of the rhGDF-5/β-TCP implants. Cartilage was not found in any region and residues of carrier β-TCP were seen in the middle area. At the site of the received controlimplants, the bulk of implanted β-TCP particles remained within the sinus. At 12 weeks, the large new trabecular bone extended to the original bone surfaces in the center of the implant site of the rhGDF-5/β-TCP implants. At the control site, little new cancellous bone was formed in the middle area. At 16 weeks, rhGDF-5/β-TCP implants increased new bone formation with the lapse of time and β-TCP particles were almost all absorbed. The present study showed that rhGDF-5 coated on β-TCP matrix successfully it maybe induced bone formation in the floor of the frontal sinus in a suitable animal model. Therfore, we conclude that the β-TCP matrix with rhGDF-5 could provide an acceptable biomaterial for maxillary sinus floor augmentation.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_2_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN0008135X","subitem_source_identifier_type":"NCID"}]},"item_2_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Fixed Prosthodontics, School of Dentistry, Health Sciences University of Hokkaido/Deparment of Oral Pathofogy, School of Dentistry, Health Sciences University of Hokkaido/Deparment of Dentai Radiology, School of Dentistry, Health Sciences University of Hokkaido/Deparment of Oral Biochemistry, School of Dentistry, Health Sciences University of Hokkaido"}]},"item_2_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"北海道医療大学歯学部歯科補綴学第二講座/北海道医療大学歯学部口腔病理学講座/北海道医療大学歯学部歯科放射線学講座/北海道医療大学歯学部口腔生化学講座"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2002-06-30"}],"displaytype":"detail","filename":"KJ00000095983.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"<原著>Growth Differentiation Factor-5/β-TCP複合体によるビーグル犬前頭洞内骨形成に関する実験的研究","objectType":"fulltext","url":"https://hsuh.repo.nii.ac.jp/record/8711/files/KJ00000095983.pdf"},"version_id":"a220e15b-02e5-4051-a608-be7420302c83"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"GDF-5","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"β-TCP","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Sinus Lift","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Beagle Dog","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Frontal Sinus","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"<原著>Growth Differentiation Factor-5/β-TCP複合体によるビーグル犬前頭洞内骨形成に関する実験的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"<原著>Growth Differentiation Factor-5/β-TCP複合体によるビーグル犬前頭洞内骨形成に関する実験的研究","subitem_title_language":"ja"},{"subitem_title":"<ORIGINAL REPORT>An experimental study of bone formation in the beagl dog frontal sinus induced by β-tricalcium phosphate matrix with growth differentiation factor-5 implants","subitem_title_language":"en"}]},"item_type_id":"2","owner":"17","path":["570"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2002-06-30"},"publish_date":"2002-06-30","publish_status":"0","recid":"8711","relation_version_is_last":true,"title":["<原著>Growth Differentiation Factor-5/β-TCP複合体によるビーグル犬前頭洞内骨形成に関する実験的研究"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2024-02-27T23:59:26.842467+00:00"}