@article{oai:hsuh.repo.nii.ac.jp:00008878,
 author = {設楽, 彰子 and 谷村, 明彦 and 根津, 顕弘 and 森田, 貴雄 and 東城, 庸介},
 issue = {1},
 journal = {東日本歯学雑誌},
 month = {Jun},
 note = {P(論文), The mechanisms for cross-desensitization between protease-activated receptor (PAR)-1 and PAR-2 in human parotid cell line, HSY-EA1 cells were examined. The HSY-EA1 cells strongly expressed mRNAs for PAR-1 and PAR-2, whereas the expression of PAR-3 and PAR-4 was very limited. Stimulation of HSY-EA1 cells with various concentrations of thrombin or trypsin produced a striking increase in [Ca^<2+>]_i followed by a slow return to the basal level within 2-3 min. When cells were pretreated with various concentrations of trypsin, the subsequent Ca^<2+> response with thrombin diminished in a dose-dependent manner over the trypsin concentration, indicating that trypsin desensitized PAR-1. The desensitization of the thrombin-induced Ca^<2+> response was also induced by the pretreatment with PAR-2 agonist peptide, SLIGKV. These results suggest that trypsin-induced inactivation of PAR-1 is due to the heterologous desensitization of PAR-1 through the activation of PAR-2 in addition to a proteolytic degradation of PAR-1.},
 pages = {61--67},
 title = {HSY-EAl細胞におけるprotease-activated receptor (PAR)-1とPAR-2の相互脱感作機構},
 volume = {23},
 year = {2004}
}