{"created":"2023-05-15T11:32:26.170325+00:00","id":8878,"links":{},"metadata":{"_buckets":{"deposit":"331610ad-d486-4c99-8559-8c343869d454"},"_deposit":{"created_by":17,"id":"8878","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"8878"},"status":"published"},"_oai":{"id":"oai:hsuh.repo.nii.ac.jp:00008878","sets":["89:573"]},"author_link":["26679","26680","26681","26682","26683"],"item_1693191265938":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_2_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"67","bibliographicPageStart":"61","bibliographicVolumeNumber":"23","bibliographic_titles":[{"bibliographic_title":"東日本歯学雑誌","bibliographic_titleLang":"ja"}]}]},"item_2_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"設楽, 彰子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"26679","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"谷村, 明彦","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"26680","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"根津, 顕弘","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"26681","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森田, 貴雄","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"26682","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"東城, 庸介","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"26683","nameIdentifierScheme":"WEKO"}]}]},"item_2_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_2_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"The mechanisms for cross-desensitization between protease-activated receptor (PAR)-1 and PAR-2 in human parotid cell line, HSY-EA1 cells were examined. The HSY-EA1 cells strongly expressed mRNAs for PAR-1 and PAR-2, whereas the expression of PAR-3 and PAR-4 was very limited. Stimulation of HSY-EA1 cells with various concentrations of thrombin or trypsin produced a striking increase in [Ca^<2+>]_i followed by a slow return to the basal level within 2-3 min. When cells were pretreated with various concentrations of trypsin, the subsequent Ca^<2+> response with thrombin diminished in a dose-dependent manner over the trypsin concentration, indicating that trypsin desensitized PAR-1. The desensitization of the thrombin-induced Ca^<2+> response was also induced by the pretreatment with PAR-2 agonist peptide, SLIGKV. These results suggest that trypsin-induced inactivation of PAR-1 is due to the heterologous desensitization of PAR-1 through the activation of PAR-2 in addition to a proteolytic degradation of PAR-1.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_2_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN0008135X","subitem_source_identifier_type":"NCID"}]},"item_2_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Dental Pharmacology, School of Dentistry, Health Sciences University of Hokkaido"}]},"item_2_text_2":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"原著"}]},"item_2_text_3":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"ORIGINAL"}]},"item_2_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"北海道医療大学歯学部歯科薬理学教室"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2004-06-01"}],"displaytype":"detail","filename":"KJ00004266358.pdf","filesize":[{"value":"495.6 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"HSY-EAl細胞におけるprotease-activated receptor (PAR)-1とPAR-2の相互脱感作機構","objectType":"fulltext","url":"https://hsuh.repo.nii.ac.jp/record/8878/files/KJ00004266358.pdf"},"version_id":"e4ab5097-80dd-4899-bd65-d790d378ae6a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"protease-activated receptor (PAR)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"thrombin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"trypsin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"SLIGKV","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"desensitization","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"HSY-EAl細胞におけるprotease-activated receptor (PAR)-1とPAR-2の相互脱感作機構","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"HSY-EAl細胞におけるprotease-activated receptor (PAR)-1とPAR-2の相互脱感作機構","subitem_title_language":"ja"},{"subitem_title":"Cross-desensitization between PAR-1 and PAR-2 in HSY-EA 1 cells.","subitem_title_language":"en"}]},"item_type_id":"2","owner":"17","path":["573"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2004-06-01"},"publish_date":"2004-06-01","publish_status":"0","recid":"8878","relation_version_is_last":true,"title":["HSY-EAl細胞におけるprotease-activated receptor (PAR)-1とPAR-2の相互脱感作機構"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2024-02-28T00:04:41.354177+00:00"}