@article{oai:hsuh.repo.nii.ac.jp:00009912,
 author = {東城, 庸介 and Tojyo, Yosuke},
 issue = {1},
 journal = {北海道医療大学歯学雑誌},
 month = {Jun},
 note = {P(論文), Calcium ion (Ca^<2+>) plays an essential role as a second messenger in secretion of water and electrolytes in salivary glands. Many studies using fluorescent Ca^<2+> indicators such as quin-2 and fura-2 have shown that stimulation of muscarinic, α-adrenergic, or substance P receptors cause a rapid increase in [Ca^<2+>]_i in salivary gland cells resulting from the production of inositol 1,4,5-trisphosphate (IP_3). The [ra～<2+>]_i response is attributed to Ca^<2+> release from intracellular Ca^<2+> store followed by Ca^<2+> entry across the plasma membrane. The increase in [Ca^<2+>]_i is initiated in the apical pole of acinar cells and then rapidly spreads as a Ca^<2+> wave toward the basolateral region. The apical-to-basal pattern of Ca^<2+> signaling is probably important to activate the ion transport systems in salivary glands. In this review, I discuss mechanisms and physiological significance of the polarized Ca^<2+> signaling in salivary gland cells.},
 pages = {1--11},
 title = {カルシウムシグナルと唾液分泌機能},
 volume = {24},
 year = {2005}
}