{"created":"2023-05-15T11:32:30.259285+00:00","id":9912,"links":{},"metadata":{"_buckets":{"deposit":"77d4f79b-9967-41b3-9a10-7f91ff9a8bb7"},"_deposit":{"created_by":17,"id":"9912","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"9912"},"status":"published"},"_oai":{"id":"oai:hsuh.repo.nii.ac.jp:00009912","sets":["157:598"]},"author_link":["32084","32086"],"item_2_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-06-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"11","bibliographicPageStart":"1","bibliographicVolumeNumber":"24","bibliographic_titles":[{"bibliographic_title":"北海道医療大学歯学雑誌","bibliographic_titleLang":"ja"}]}]},"item_2_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"東城, 庸介","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"32084","nameIdentifierScheme":"WEKO"}]}]},"item_2_creator_8":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tojyo, Yosuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"32086","nameIdentifierScheme":"WEKO"}]}]},"item_2_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_2_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"Calcium ion (Ca^<2+>) plays an essential role as a second messenger in secretion of water and electrolytes in salivary glands. Many studies using fluorescent Ca^<2+> indicators such as quin-2 and fura-2 have shown that stimulation of muscarinic, α-adrenergic, or substance P receptors cause a rapid increase in [Ca^<2+>]_i in salivary gland cells resulting from the production of inositol 1,4,5-trisphosphate (IP_3). The [ra～<2+>]_i response is attributed to Ca^<2+> release from intracellular Ca^<2+> store followed by Ca^<2+> entry across the plasma membrane. The increase in [Ca^<2+>]_i is initiated in the apical pole of acinar cells and then rapidly spreads as a Ca^<2+> wave toward the basolateral region. The apical-to-basal pattern of Ca^<2+> signaling is probably important to activate the ion transport systems in salivary glands. In this review, I discuss mechanisms and physiological significance of the polarized Ca^<2+> signaling in salivary gland cells.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_2_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA12060694","subitem_source_identifier_type":"NCID"}]},"item_2_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Dental Pharmacology, School of Dentistry, Health Sciences University of Hokkaido"}]},"item_2_text_2":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"総設"}]},"item_2_text_3":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"REVIEW"}]},"item_2_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"北海道医療大学小児外科学部歯科薬理学講座"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2005-06-30"}],"displaytype":"detail","filename":"KJ00004178304.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"カルシウムシグナルと唾液分泌機能","objectType":"fulltext","url":"https://hsuh.repo.nii.ac.jp/record/9912/files/KJ00004178304.pdf"},"version_id":"5b0b1a14-312b-49bc-a5ef-04dc4385d570"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"カルシウムシグナル","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"唾液腺","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"唾液分泌","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"カルシウム蛍光指示薬","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"イメージング","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"カルシウムシグナルと唾液分泌機能","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"カルシウムシグナルと唾液分泌機能","subitem_title_language":"ja"},{"subitem_title":"Clcium signaling and salivary secretory function","subitem_title_language":"en"}]},"item_type_id":"2","owner":"17","path":["598"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2005-06-30"},"publish_date":"2005-06-30","publish_status":"0","recid":"9912","relation_version_is_last":true,"title":["カルシウムシグナルと唾液分泌機能"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2024-02-28T04:43:39.070917+00:00"}