@article{oai:hsuh.repo.nii.ac.jp:00009995,
 author = {SAKURAI, Yasumasa and ECHIGO, Seishi and KUCHIIWA, Satoshi and IZUMI, Hiroshi},
 issue = {2},
 journal = {北海道医療大学歯学雑誌},
 month = {Dec},
 note = {P(論文), The aim of the present study was to investigate whether electrical stimulation of the unilateral central cut ends of the lingual nerve produces trigeminal-parasympathetic reflex vasodilatation in both sides of the lower lip and stimulates neurons in the trigeminal nuclear complex in rats subjected to cervical vagosympathectomy, deeply anesthetized with urethane and artificially ventilated. Immunohistochemical detection of c-Fos expression was used to assess the impact of prolonged lingual nerve stimulation. We found that unilateral lingual nerve stimulation at 10min intervals for 200min produced the following: (1) consistent blood flow increases predominantly in the ipsilateral side of the lower lip, (2) more profound expression of c-Fos protein ipsilaterally in all subnuclei of the trigeminal spinal nucleus (Vsp) except the trigeminal subnucleus oralis, (3) a greater number of c-Fos-positive neurons in the ipsilateral trigeminal subnucleus interpolaris/caudalis transition zone (Vi/Vc) compared with the four other areas (trigeminal subnucleus caudalis/upper cervical spinal cord transition zone, subnucleus caudalis, subnucleus interpolaris, and subnucleus oralis) of the Vsp, and (4) no statistically significant increase in c-Fos expression in all subnuclei of the Vsp of the contralateral side in comparison with the control rats. The present studies and our previous data suggest that impulses elicited by electrical stimulation of the lingual nerve converge on the ipsilateral Vi/Vc in the Vsp and that the parasympathetic vasodilator neurons and salivatory nucleus, after receiving projections from the Vi/Vc in the Vsp, project to the lower lip via the otic ganglion.},
 pages = {97--107},
 title = {Lingual nerve stimulation-induced c-Fos expression in the trigeminal spinal nucleus},
 volume = {25},
 year = {2006}
}