WEKO3
アイテム
{"_buckets": {"deposit": "b9d08d7c-3180-4b66-8803-c20a24f2dded"}, "_deposit": {"created_by": 17, "id": "8502", "owners": [17], "pid": {"revision_id": 0, "type": "depid", "value": "8502"}, "status": "published"}, "_oai": {"id": "oai:hsuh.repo.nii.ac.jp:00008502", "sets": ["565"]}, "author_link": ["25912"], "item_2_biblio_info_14": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1999-12-30", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "361", "bibliographicPageStart": "347", "bibliographicVolumeNumber": "18", "bibliographic_titles": [{"bibliographic_title": "東日本歯学雑誌", "bibliographic_titleLang": "ja"}]}]}, "item_2_creator_6": {"attribute_name": "著者名(日)", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "北所, 弘行", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "25912", "nameIdentifierScheme": "WEKO"}]}]}, "item_2_description_1": {"attribute_name": "ページ属性", "attribute_value_mlt": [{"subitem_description": "P(論文)", "subitem_description_language": "ja", "subitem_description_type": "Other"}]}, "item_2_description_12": {"attribute_name": "抄録(英)", "attribute_value_mlt": [{"subitem_description": "To observe the effect of Hepatocyte growth factor/scatter factor (HGF/SF) on the invasion and metastasis of human oral squamous cell carcinoma (SCO cells, the invasive ability and internal signal transduction were examined The invasive ability of tumor cells (SAS, HSC-3,Ca9-22) was enhanced dose-dependently by HGF/SF stimulation, and C3 exoenzyme which is a specific inhibitor of Rho activation significantly reduced the invasive ability of SAS cells The HGF/SF stimulation enhanced the tyrosin phosphorylation of HGF receptors (c-Met) and focal adhesion kmase (FAK^\u003cp125\u003e) of SAS cells, and C3 exoenzyme completely inhibited the activation of FAK^\u003cp125\u003e It was observed that Rho protein located around the nuclear area translocated to the membrane area and subsequently increased in the cytolysate, following HGF/SF stimulation These results suggest that the activation of FAK^\u003cp125\u003e caused by phosphorylation of c-Met may enhance the HGF/SF, inducing invasive ability and that Rho protein possibly regulates the activation of FAK^\u003cp125\u003e through the translocation itself", "subitem_description_language": "en", "subitem_description_type": "Other"}]}, "item_2_source_id_13": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN0008135X", "subitem_source_identifier_type": "NCID"}]}, "item_2_text_10": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Second Department of Oral and Maxillofacial Surgery, a School of Dentistry, Health Sciences University of Hokkaido"}]}, "item_2_text_9": {"attribute_name": "著者所属(日)", "attribute_value_mlt": [{"subitem_text_language": "ja", "subitem_text_value": "北海道医療大学歯学部口腔外科学第二講座"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "1999-12-30"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00000095773.pdf", "filesize": [{"value": "1.5 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "application/pdf", "size": 1500000.0, "url": {"label": "\u003c原著\u003e肝細胞増殖因子(HGF/SF)によるヒト口腔扁平上皮癌細胞の浸潤シグナルの検討 : 特に低分子量GTP結合蛋白質Rhoの関与について", "objectType": "fulltext", "url": "https://hsuh.repo.nii.ac.jp/record/8502/files/KJ00000095773.pdf"}, "version_id": "80959934-013b-41d5-a935-c2744331b85e"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Hepatocyte growth factor", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Intraceller signal transductin", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Invasion", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Small GTP binding protein", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Oral squamous cell carcinoma", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "\u003c原著\u003e肝細胞増殖因子(HGF/SF)によるヒト口腔扁平上皮癌細胞の浸潤シグナルの検討 : 特に低分子量GTP結合蛋白質Rhoの関与について", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "\u003c原著\u003e肝細胞増殖因子(HGF/SF)によるヒト口腔扁平上皮癌細胞の浸潤シグナルの検討 : 特に低分子量GTP結合蛋白質Rhoの関与について", "subitem_title_language": "ja"}, {"subitem_title": "\u003cORIGINAL ARTICLE\u003eStudy of invasive signal transduction of human oral squamous cell carcinoma cell lines by hepatocyte growth fator/scatter factor : Especialy the relation of small GTP binding protein Rho", "subitem_title_language": "en"}]}, "item_type_id": "2", "owner": "17", "path": ["565"], "permalink_uri": "https://hsuh.repo.nii.ac.jp/records/8502", "pubdate": {"attribute_name": "PubDate", "attribute_value": "1999-12-30"}, "publish_date": "1999-12-30", "publish_status": "0", "recid": "8502", "relation": {}, "relation_version_is_last": true, "title": ["\u003c原著\u003e肝細胞増殖因子(HGF/SF)によるヒト口腔扁平上皮癌細胞の浸潤シグナルの検討 : 特に低分子量GTP結合蛋白質Rhoの関与について"], "weko_shared_id": -1}
<原著>肝細胞増殖因子(HGF/SF)によるヒト口腔扁平上皮癌細胞の浸潤シグナルの検討 : 特に低分子量GTP結合蛋白質Rhoの関与について
https://hsuh.repo.nii.ac.jp/records/8502
https://hsuh.repo.nii.ac.jp/records/850238c7af86-13eb-4222-88c4-d9bb59a85c07
名前 / ファイル | ライセンス | アクション |
---|---|---|
<原著>肝細胞増殖因子(HGF/SF)によるヒト口腔扁平上皮癌細胞の浸潤シグナルの検討 : 特に低分子量GTP結合蛋白質Rhoの関与について (1.5 MB)
|
|
Item type | 紀要論文(ELS) / Departmental Bulletin Paper(ELS)(1) | |||||
---|---|---|---|---|---|---|
公開日 | 1999-12-30 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | <原著>肝細胞増殖因子(HGF/SF)によるヒト口腔扁平上皮癌細胞の浸潤シグナルの検討 : 特に低分子量GTP結合蛋白質Rhoの関与について | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | <ORIGINAL ARTICLE>Study of invasive signal transduction of human oral squamous cell carcinoma cell lines by hepatocyte growth fator/scatter factor : Especialy the relation of small GTP binding protein Rho | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Hepatocyte growth factor | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Intraceller signal transductin | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Invasion | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Small GTP binding protein | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Oral squamous cell carcinoma | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ページ属性 | ||||||
内容記述タイプ | Other | |||||
内容記述 | P(論文) | |||||
言語 | ja | |||||
著者名(日) |
北所, 弘行
× 北所, 弘行 |
|||||
著者所属(日) | ||||||
ja | ||||||
北海道医療大学歯学部口腔外科学第二講座 | ||||||
著者所属(英) | ||||||
en | ||||||
Second Department of Oral and Maxillofacial Surgery, a School of Dentistry, Health Sciences University of Hokkaido | ||||||
抄録(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | To observe the effect of Hepatocyte growth factor/scatter factor (HGF/SF) on the invasion and metastasis of human oral squamous cell carcinoma (SCO cells, the invasive ability and internal signal transduction were examined The invasive ability of tumor cells (SAS, HSC-3,Ca9-22) was enhanced dose-dependently by HGF/SF stimulation, and C3 exoenzyme which is a specific inhibitor of Rho activation significantly reduced the invasive ability of SAS cells The HGF/SF stimulation enhanced the tyrosin phosphorylation of HGF receptors (c-Met) and focal adhesion kmase (FAK^<p125>) of SAS cells, and C3 exoenzyme completely inhibited the activation of FAK^<p125> It was observed that Rho protein located around the nuclear area translocated to the membrane area and subsequently increased in the cytolysate, following HGF/SF stimulation These results suggest that the activation of FAK^<p125> caused by phosphorylation of c-Met may enhance the HGF/SF, inducing invasive ability and that Rho protein possibly regulates the activation of FAK^<p125> through the translocation itself | |||||
言語 | en | |||||
雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN0008135X | |||||
書誌情報 |
ja : 東日本歯学雑誌 巻 18, 号 2, p. 347-361, 発行日 1999-12-30 |