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DMBA頬嚢癌形成過程におけるTPA塗布のGGT陽性巣に対する効果
https://hsuh.repo.nii.ac.jp/records/7240
https://hsuh.repo.nii.ac.jp/records/724000f2d6f0-c424-450b-84af-a70b8afe719e
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
DMBA頬嚢癌形成過程におけるTPA塗布のGGT陽性巣に対する効果 (1.2 MB)
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| Item type | 紀要論文(ELS) / Departmental Bulletin Paper(ELS)(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 1986-06-01 | |||||
| タイトル | ||||||
| タイトル | DMBA頬嚢癌形成過程におけるTPA塗布のGGT陽性巣に対する効果 | |||||
| 言語 | ja | |||||
| タイトル | ||||||
| タイトル | Effect of Applications of TPA for GGT-Positive Foci during DMBA-Induced Cheek Pouch Carcinogenesis of the Hamster | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | DMBA | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | TPA | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | GGT-positive foci | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | cheek pouch carcinogenesis | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| ページ属性 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | P(論文) | |||||
| 言語 | ja | |||||
| 記事種別(日) | ||||||
| 原著 | ||||||
| 記事種別(英) | ||||||
| en | ||||||
| ORIGINAL ARTICLE | ||||||
| 著者名(日) |
舘山, 美樹
× 舘山, 美樹× 中出, 修× 大内, 知之× 八重樫, 和秀× 吉川, 泰子× 賀来, 亨× 奥山, 富三 |
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| 著者所属(日) | ||||||
| ja | ||||||
| 東日本学園大学歯学部口腔病理学講座 | ||||||
| 著者所属(英) | ||||||
| en | ||||||
| Department of Oral Pathology, School of Dentistry, HIGASHI-NIPPON-GAKUEN UNIVERSITY | ||||||
| 著者所属(英) | ||||||
| en | ||||||
| 抄録(英) | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The effect of repeated applications of the skin-tumor promoter 12-0-tetradecanoyl- phorbol-13-acetate (TPA) following treatment with the carcinogen 0.5% 9,10-dimethyl-1, 2-benzanthracene in mineral oil (DMBA) was examined in hamster cheek pouch carcinogenesis. The animals were divided into three groups in our experiment. The animals in Group 1 were treated with biweekly topical applications of DMBA for 5 weeks followed by biweekly applications of TPA during the experiment. The animals in Group 2 were treated with DMBA for 5 weeks and then left untreated during the experiment. The animals in Group 3 used as control were treated with mineral oil for 5 weeks followed by biweekly applications of TPA during the experiment. γ-glutamyl transpeptidase stained cells were rapidly induced in the epithelium of hamster cheek pouch treated with biweekly applications of DMBA. During the five consecutive weeks of DMBA treatment progressively numerous GGT-stained epithelial cell populations (715±219 foci/lOcm^2) and larger GGT-positive foci up to about 0.90 mm in diameter were encountered. The majority of the GGT-positive foci induced by 10 applications of DMBA disappeared when carcinogen application was discontinued both in Group 1 and in Group 2 . A comparison of GGT-positive foci at the completion of the DMBA regimen and at 10 weeks thereafter revealed no significant decrease-in the size of foci in both Group 1 and Group 2 . In the present study, the tumor promoter, TPA, is shown to be inaffective in increasing of numbers and size of GGT-positive foci after DMBA application was discontinued. | |||||
| 言語 | en | |||||
| 雑誌書誌ID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN0008135X | |||||
| 書誌情報 |
ja : 東日本歯学雑誌 巻 5, 号 1, p. 31-39, 発行日 1986-06 |
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| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
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Cite as
舘山, 美樹, 中出, 修, 大内, 知之, 八重樫, 和秀, 吉川, 泰子, 賀来, 亨, 奥山, 富三, 1986, DMBA頬嚢癌形成過程におけるTPA塗布のGGT陽性巣に対する効果: 31–39 p.
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