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<原著>Endogenous Oxygen Radical Scavengerによるマウス退縮型癌細胞の悪性化進展の抑制に関する研究
https://hsuh.repo.nii.ac.jp/records/8045
https://hsuh.repo.nii.ac.jp/records/804508bc5879-864e-4f83-83da-08acb8d1ed5d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
<原著>Endogenous Oxygen Radical Scavengerによるマウス退縮型癌細胞の悪性化進展の抑制に関する研究 (1.3 MB)
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| Item type | 紀要論文(ELS) / Departmental Bulletin Paper(ELS)(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 1994-12-31 | |||||
| タイトル | ||||||
| タイトル | <原著>Endogenous Oxygen Radical Scavengerによるマウス退縮型癌細胞の悪性化進展の抑制に関する研究 | |||||
| 言語 | ja | |||||
| タイトル | ||||||
| タイトル | <ORIGINAL ARTICLE>A Study of Objective Assessment for Tooth Cavity Preparation at Preclinical Restorative Dentistry. : Part 1. Student Self-assessment for Tooth Cavity | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Tumor progression | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | oxygen radical scavenger | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Metallothionein | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Bismuth sub-nitrate | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | PSK | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| ページ属性 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | P(論文) | |||||
| 著者名(日) |
加藤, 元康
× 加藤, 元康 |
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| 著者所属(日) | ||||||
| ja | ||||||
| 北海道医療大学歯学部 | ||||||
| 著者所属(英) | ||||||
| en | ||||||
| Second Department of Oral Surgery, School of Dentistry, HELTH SCIENCES UNIVERSITY OF HOKKAIDO | ||||||
| 抄録(英) | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | QR-32 cell is low tumorigemc and low metastatic clone derived from 3-methy cholanthrene induced C57BL/6 mouse fibrosarcoma (BMT-11). When QR-32 cells (2×10^5) were sub-cutaneously implanted or 10^6 cells were intravenously injected into normal mice, they all spontaneously regressed. However, when they were subcutaneously co-implanted with gelatin sponge (10×5×3mm), they acquired enhancement of tumorigenicity and metastatic ability and grew lethally. Previous in vitro assays have shown that this malignant progression of QR-32 cells was caused by oxygen radicals released from host cells reactive to gelatin sponge To elucidate the effects of oxygen radicals in vivo, this study examined whether endogeous oxygen radical scavengers induced by bismuth submtrate (BSN) or PSK administration inhibited the malignant progression of QR-32 cells. The QR-32 (2×10^5) cells and gelatin sponge were subcutaneously co-implanted into mice, pre-administered with BSN (5mg/kg/day) or PSK (150mg/kg/day, i p, 1000mg/kg/day p o). The BSN and PSK administration did not affect the tumor growth. The culture lines from these tumors arising in mice were established implanted with QR-32 cells and gelatin sponge, and implanted these culture tumor cells s c or i v into normal mice. Compared with the parental QR-32 cells, the tumor cell lines developed in the normal mice and used for the malignant progression estimation , i e s. c tumorigenicity and i v lung metastasis. All 18 cell lines (100%) obtained from the untreated group showed progress in the malignancy when compared with QR-32 cells However, these cell lines obtained from the BSN administered group indicated malignant progression in only 4 out of 7 cell lines (57.1%), in the same manner cell lines obtained from the PSK (i p) group indicated malignant progression in 3 out of 6 cell lines (50%), for cell lines obtained from PSK (p o ) group indicated in 4 out of 8 cell lines (50%). Endogeous radical scavengers in tumor in mice administered with BSN or PSK were analysed with the immunoblotting and immunohistostaming. These results of the assay showed that the quantity of radical scavengers (metallothionein, Mn-SOD, Cu/Zn-SOD GSH-Px, Catalase) increased over the untreted groups. These findings suggest that oxygen radicals may play an important role in in vivo QR-32 malignancy progress. | |||||
| 言語 | en | |||||
| 雑誌書誌ID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN0008135X | |||||
| 書誌情報 |
ja : 東日本歯学雑誌 巻 13, 号 2, p. 245-257, 発行日 1994-12-31 |
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| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
