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<原著>PDGF-BBとIGF-Iがラット歯髄由来線維芽細胞に及ぼす影響
https://hsuh.repo.nii.ac.jp/records/8317
https://hsuh.repo.nii.ac.jp/records/8317682d99dc-b7dd-4f77-9ac1-96bc8b265d44
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
<原著>PDGF-BBとIGF-Iがラット歯髄由来線維芽細胞に及ぼす影響 (2.0 MB)
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| Item type | 紀要論文(ELS) / Departmental Bulletin Paper(ELS)(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 1997-12-30 | |||||
| タイトル | ||||||
| タイトル | <原著>PDGF-BBとIGF-Iがラット歯髄由来線維芽細胞に及ぼす影響 | |||||
| 言語 | ja | |||||
| タイトル | ||||||
| タイトル | <ORIGINAL ARTICLE>Effects of PDGF-BB and IGF-l on rat dental pulp fibroblasts | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Pulp fibroblasts | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Platelet-derived growth factor (PDGF) | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Insulin-like growth factor (IGF) | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Transforming growth factor-β1 (TGF-β1) | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Bone morphogenetic proteins (BMPs) | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| ページ属性 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | P(論文) | |||||
| 言語 | ja | |||||
| 著者名(日) |
蔵口, 潤
× 蔵口, 潤× 中出, 修× 安彦, 善裕× 賀来, 亨 |
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| 著者所属(日) | ||||||
| ja | ||||||
| 北海道医療大学歯学部 | ||||||
| 著者所属(英) | ||||||
| en | ||||||
| Department of Oral Pathology, School of Dentistry, Health Sciences University of Hokkaido | ||||||
| 抄録(英) | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Dental pulp cells are able to differentiate into odontoblasts and to form dentin when stimulated by external irritation. Growth factors such as platelet-derived growth factor (PDGF), insulin-like growth factor (IGF), and transforming growth factor-β (TGF-β) as well as bone morphogenetic proteins (BMPs) have been implicated in the regulation of the wound healing of pulp in vitro, but the effects of these growth factors on the function of dental pulp fibroblasts in vitro still remain to be established. This study examined the effects of the best characterized growth factors in mesenchymal cells, PDGF-BB and IGF-I on cell proliferation, cell differentiation, chemotactic activity and the gene expression of other growth factors, such as BMP-1～5 and TGF-β1 in rat pulpfibroblasts in vitro. The results are as follows. 1. Both PDGF-BB and IGF-I significantly stimulated cell proliferation and chemotactic activity in rat pulp fibroblasts in vitro, and more pronounced effects were observed in PDGF-BB. 2. Mitogenic doses of PDGF-BB inhibited the alkaline phosphatase (ALP) activity, significantly, while mitogenic doses of IGF-I did not have significant effect on ALP. 3. Short term treatment with mitogenic doses of IGF-I increased mRNA levels of BMP-4 and TGF-β1 in,a dose-dependent manner, while long term treatment did not result in significant effects on the mRNA levels of BMPs and TGF-β1. 4. There were no significant effects on the gene expression of BMP-1～5 and TGF-β1, when the cells were treated with PDGF-BB. These results indicate that both PDGF-BB and IGF-I are mitogenic to rat dental pulpfibroblasts, but that they act in different manners to regulate the function of the dental pulp. | |||||
| 言語 | en | |||||
| 雑誌書誌ID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN0008135X | |||||
| 書誌情報 |
ja : 東日本歯学雑誌 巻 16, 号 2, p. 247-259, 発行日 1997-12-30 |
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