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<原著>後天性von Willebrand症候群における出血機序およびその発生原因の検討
https://hsuh.repo.nii.ac.jp/records/8318
https://hsuh.repo.nii.ac.jp/records/831874cb73f3-74cd-4612-86b9-fea6374f9da4
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
<原著>後天性von Willebrand症候群における出血機序およびその発生原因の検討 (1.1 MB)
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| Item type | 紀要論文(ELS) / Departmental Bulletin Paper(ELS)(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 1997-12-30 | |||||
| タイトル | ||||||
| タイトル | <原著>後天性von Willebrand症候群における出血機序およびその発生原因の検討 | |||||
| 言語 | ja | |||||
| タイトル | ||||||
| タイトル | <ORIGINAL ARTICLE>Study on the mechanism of bleeding in acquired von Willebrand syndrome | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Von Willebrand factor | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Acquired von Willebrand syndrome | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Essential thrombocythemia | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Systemic lupus erythematosus | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| ページ属性 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | P(論文) | |||||
| 言語 | ja | |||||
| 著者名(日) |
家子, 正裕
× 家子, 正裕× 安河内, 太郎× 河野, 通史× 能登谷, 京× 垂水, 隆志× 沢田, 賢一× 小池, 隆夫 |
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| 著者所属(日) | ||||||
| ja | ||||||
| 北海道医療大学歯学部内科/北海道医療大学医科学研究センター/市立札幌病院免疫血液内科/北海道大学医学部第二内科 | ||||||
| 著者所属(英) | ||||||
| en | ||||||
| Department of Internal Medicine, Health Science University of Hokkaido/Institute of Medical Science, Health Science University of Hokkaido/Department of Clinical Hematology and Immunology, Sapporo City General Hospital/Department of Clinical Hematology and Immunology, Sapporo City General Hospital/Second Department of Internal Medicine, Hokkaido University School of Medicine/Second Department of Internal Medicine, Hokkaido University School of Medicine/Second Department of Internal Medicine, Hokkaido University School of Medicine | ||||||
| 抄録(英) | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The mechanism of bleeding in acquired von Willebrand syndrome (a-vWS), which is associated with several kinds of disorders, is not established. This report investigated the pathogenesis of a-vWS associated with essential thrombocythemia (ET) and systemic lupus erythematosus (SLE). Bleeding times lengthened in 6 of 8 patients with ET; the ristocetin cofactor activity (RCof) decreased in 6 other patients, while von Willebrand factor (vWF) large multimers decreased in all patients. In three cases these abnormalities improved after platelet counts decreased following administration of busulfan. The decrease of vWF large multimers correlated with the platelet counts, but not with the plasma concentration of plasmin or elastase. In a case of SLE, plasma from an untreated period inhibited the RCof of normal plasma, suggesting that the patient plasma contained an inhibitor to vWF activity. The inhibited RCof fraction was purified with sephacryl S-300 gel filtration, DEAE sephacel column chromatography, and Mono Q column chromatography, and the molecular weight shown SDS-PAGE was about 1000kd. Electrophoresis with anti-human IgA antibody confirmed this fraction to contain IgA. The RCof activity improved with the addition of anti-human IgA antibody to the patientplasma. This study shows the possibility that anti-vWF IgA type autoantibody or the decrease ofvWF large multimers associated with the increase in platelets may cause a-vWS. | |||||
| 言語 | en | |||||
| 雑誌書誌ID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN0008135X | |||||
| 書誌情報 |
ja : 東日本歯学雑誌 巻 16, 号 2, p. 261-270, 発行日 1997-12-30 |
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