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Actinobacillus actinomycetemcomitans感染マクロファージのアポトーシス誘導における一酸化窒素の関与
https://hsuh.repo.nii.ac.jp/records/8693
https://hsuh.repo.nii.ac.jp/records/8693d59a360a-4e20-419f-b3bb-f31f52157057
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Actinobacillus actinomycetemcomitans感染マクロファージのアポトーシス誘導における一酸化窒素の関与 (1.0 MB)
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| Item type | 紀要論文(ELS) / Departmental Bulletin Paper(ELS)(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2001-12-31 | |||||
| タイトル | ||||||
| タイトル | Actinobacillus actinomycetemcomitans感染マクロファージのアポトーシス誘導における一酸化窒素の関与 | |||||
| 言語 | ja | |||||
| タイトル | ||||||
| タイトル | Nitric oxide-mediated protection of Actinobacillus actinomycetemcomitans-infected macrophages against apoptosis | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Actinobacillus actinomycetemcomitans | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Macrophages | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Apoptosis | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Nitric oxide | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| ページ属性 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | P(論文) | |||||
| 言語 | ja | |||||
| 記事種別(日) | ||||||
| ja | ||||||
| 原著 | ||||||
| 記事種別(英) | ||||||
| en | ||||||
| ORIGINAL REPORT | ||||||
| 著者名(日) |
富岡, 純
× 富岡, 純 |
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| 著者所属(日) | ||||||
| ja | ||||||
| 北海道医療大学歯学部歯科保存学第一講座 | ||||||
| 著者所属(英) | ||||||
| en | ||||||
| Department of Periodontology and Endodontology, School of Dentistry, Health Sciences University of Hokkaido | ||||||
| 抄録(英) | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Nitric oxide (NO) produced by activated macrophages is known to have antibacterial effects and to act as an inflammatory modulator. The aim of this study was to determine whether infected macrophages produce NO after Actinobacillus actinomycetemcomitans infection, and whetherthe produced NO is involved in regulating subsequent apoptosis. The expression of inducible NO synthetase (iNOS) was examined. In addition, culture supernatant was obtained to measure NO levels and LDH activity in the presence and absence of S-methylisourea (SMT), a specific inhibitor of iNOS. Celluler protein was extracted from infected macrophages to measure DNA fragmentation and caspase activity. The NO levels were increased by the infection. The LDH activity, DNA fragmentation, and caspase activity were also increased by the infection, and increased further with addition of SMT. These findings indicate that infected macrophages produce NO to protect themselves against apoptotic cell death by decreasing caspase activity. | |||||
| 言語 | en | |||||
| 雑誌書誌ID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN0008135X | |||||
| 書誌情報 |
ja : 東日本歯学雑誌 巻 20, 号 2, p. 159-170, 発行日 2001-12-31 |
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