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株化骨細胞MLO-Y4-A2におけるPTH受容体遺伝子のメカニカルストレスによる発現
https://hsuh.repo.nii.ac.jp/records/8879
https://hsuh.repo.nii.ac.jp/records/88799aee3844-a989-4620-b282-0ab8dc4445bc
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
株化骨細胞MLO-Y4-A2におけるPTH受容体遺伝子のメカニカルストレスによる発現 (1.6 MB)
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| Item type | 紀要論文(ELS) / Departmental Bulletin Paper(ELS)(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-06-01 | |||||
| タイトル | ||||||
| タイトル | 株化骨細胞MLO-Y4-A2におけるPTH受容体遺伝子のメカニカルストレスによる発現 | |||||
| 言語 | ja | |||||
| タイトル | ||||||
| タイトル | Mechanism of PTH receptor induction by fluid shear stress in the osteocyte-like cell line MLO-Y4-A2 | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| ページ属性 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | P(論文) | |||||
| 言語 | ja | |||||
| 記事種別(日) | ||||||
| ja | ||||||
| 原著 | ||||||
| 記事種別(英) | ||||||
| en | ||||||
| ORIGINAL | ||||||
| 著者名(日) |
岡山, 三紀
× 岡山, 三紀× 荒川, 俊哉× 谷村, 明彦× 溝口, 到× 田隈, 泰信 |
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| 著者所属(日) | ||||||
| ja | ||||||
| 北海道医療大学歯学部歯科矯正学講座 | ||||||
| 著者所属(日) | ||||||
| ja | ||||||
| 北海道医療大学歯学部口腔生化学講座 | ||||||
| 著者所属(日) | ||||||
| ja | ||||||
| 北海道医療大学歯学部歯科薬理学講座 | ||||||
| 著者所属(英) | ||||||
| en | ||||||
| Department of Orthodontics, School of Dentistry, Health Sciences University of Hokkaido | ||||||
| 著者所属(英) | ||||||
| en | ||||||
| Department of Oral Biochemistry, School of Dentistry, Health Sciences University of Hokkaido | ||||||
| 著者所属(英) | ||||||
| en | ||||||
| Department of Dental Pharmacology, School of Dentistry, Health Sciences University of Hokkaido | ||||||
| 抄録(英) | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Osteocytes are generally accepted to function as sensors for mechanical stress, which are deeply involved in bone homeostasis. However, the signal transduction mechanism of mechanical stresses in osteocytes is still mostly unclear. Here the effect of fluid shear stress on gene expressions of MLO-Y4-A2 cells, a murine osteocyte-like cell line, was investigated. When shear stress was loaded on the MLO-Y4-A2 cells, PTH receptor mRNA increased to 5 to 8 times over the control level. The PTH receptor protein and CAMP levels were also increased by the shear stress. The increase in the PTH receptor mRNA was not inhibited by U-0126 (ERK kinase inhibitor) or indomethacin (COX-2 inhibitor). Luciferase reporter analysis indicated that the P1 promoter region of the PTH receptor gene includes cis-elements for transcription control by shear stress. These results suggest that in osteocytes the mechanical stress induces PTH receptor increases, which in turn amplify the effect of PTH and/or PTHrP on bone remodeling. | |||||
| 言語 | en | |||||
| 雑誌書誌ID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN0008135X | |||||
| 書誌情報 |
ja : 東日本歯学雑誌 巻 23, 号 1, p. 69-81, 発行日 2004-06 |
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| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
