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ジフェニルヒダントイン(DPH)とリポポリサッカライド(LPS)のヒト歯肉由来培養線維芽細胞の細胞活性に対する影響
https://hsuh.repo.nii.ac.jp/records/7239
https://hsuh.repo.nii.ac.jp/records/7239993f6d2f-df29-4094-95b6-ef21be12d213
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ジフェニルヒダントイン(DPH)とリポポリサッカライド(LPS)のヒト歯肉由来培養線維芽細胞の細胞活性に対する影響 (610.0 kB)
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| Item type | 紀要論文(ELS) / Departmental Bulletin Paper(ELS)(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 1986-06-01 | |||||
| タイトル | ||||||
| タイトル | ジフェニルヒダントイン(DPH)とリポポリサッカライド(LPS)のヒト歯肉由来培養線維芽細胞の細胞活性に対する影響 | |||||
| 言語 | ja | |||||
| タイトル | ||||||
| タイトル | Effects of Diphenylhydantoin (DPH) and Lipopolysaccharide (LPS) on Cell Activities in Human Gingival Fibroblasts in vitro | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Diphenylhydantoin | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | lipopolysaccharide | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | hydroxyproline | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | fibroblast | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| ページ属性 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | P(論文) | |||||
| 言語 | ja | |||||
| 記事種別(日) | ||||||
| 原著 | ||||||
| 記事種別(英) | ||||||
| en | ||||||
| ORIGINAL ARTICLE | ||||||
| 著者名(日) |
松尾, 朗
× 松尾, 朗× 國本, 隆明× 矢嶋, 俊彦 |
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| 著者所属(日) | ||||||
| ja | ||||||
| 東日本学園大学歯学部口腔解剖学第1講座 | ||||||
| 著者所属(英) | ||||||
| en | ||||||
| Department of Oral Anatomy, School of Dentistry, HIGASHI-NIPPON-GAKUEN UNIVERSITY | ||||||
| 著者所属(英) | ||||||
| en | ||||||
| 抄録(英) | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The effects of diphenylhydantoin (DPH) and lipopolysaccharide (LPS) in culture medium on cell proliferation and several cell activities were investigated in human gingival fibroblasts. The cell proliferative rate was not affected by DPH ( 5μg/ml) and LPS (E. coli, 255μg/ml) in culture medium. DPH increased the total protein, hydroxyproline content and alkaline phosphatase (ALPase) activity of fibroblast cultures as compared with the control. LPS decreased the hydroxyproline content and ALPase activity and increased acid phosphatase (ACPase) activity of cultures, but no effect was seen on the total protein. On the other hand, the level of hydroxyproline content, ALPase activity and ACPase activity in DPH+LPS-cultures were also the same as those in LPS-cultures, whereas the total protein returned to the levels of DPH-cultures. The changes in weekly increase of hydroxyproline content of fibroblast cultures were associated with the changes of ALPase activity. The amount of hydroxyproline content could; be expressed almost completely by the collagen fibrogenesis index, which were obtained using a Monocellater^[○!R] that displayed the relative absorbance of cultures stained, with Van Gieson's solution. A striking difference seen between nonLPS- and LPS-cultures was the much higher level of noncollagenous protein found in the latter ones. These results indicate that the administration of LPS may stimulate the synthesis of noncollagenous protein in human gingival fibroblasts, and this was particularly enhanced in presence of DPH. | |||||
| 言語 | en | |||||
| 雑誌書誌ID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN0008135X | |||||
| 書誌情報 |
ja : 東日本歯学雑誌 巻 5, 号 1, p. 21-30, 発行日 1986-06 |
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| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
