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<ORIGINAL ARTICLE>Inhibitory effects of extracellular ATP on the Ca^<2+> mobilization evoked by muscarinic stimulation in rat parotid acinar cells
https://hsuh.repo.nii.ac.jp/records/8310
https://hsuh.repo.nii.ac.jp/records/8310d1677a5c-c73e-4da9-8052-66116e53810e
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
<ORIGINAL ARTICLE>Inhibitory effects of extracellular ATP on the Ca^<2+> mobilization evoked by muscarinic stimulation in rat parotid acinar cells (388.9 kB)
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| Item type | 紀要論文(ELS) / Departmental Bulletin Paper(ELS)(1) | |||||
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| 公開日 | 1997-12-30 | |||||
| タイトル | ||||||
| タイトル | <ORIGINAL ARTICLE>Inhibitory effects of extracellular ATP on the Ca^<2+> mobilization evoked by muscarinic stimulation in rat parotid acinar cells | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Parotid acinar cells | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | ATP | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Purinergic receptors | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Intracellular Ca^<2+> | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Phosphoinositide hydrolysis | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| ページ属性 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | P(論文) | |||||
| 言語 | ja | |||||
| 著者名(日) |
Yosuke, TOJYO
× Yosuke, TOJYO× TANIMURA, Akihiko× MATSUMOTO, Yoshito |
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| 著者名(英) |
TOJYO, Yosuke
× TOJYO, Yosuke× TANIMURA, Akihiko× MATSUMOTO, Yoshito |
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| 著者所属(日) | ||||||
| ja | ||||||
| 北海道医療大学歯学部 | ||||||
| 著者所属(英) | ||||||
| en | ||||||
| Department of Dental Pharmacology, School of Dentistry, Health Sciences University of Hokkaido | ||||||
| 抄録(英) | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | In rat parotid acinar cells, extracellular ATP reduced the increase in cytosolic Ca^<2+> concentration ([Ca^<2+>]_i) induced by the muscarinic receptor agonist carbachol (CCh) dose-dependently. This inhibitory effect was also observed in the absence of extracellular Ca^<2+>, indicating that the Ca^<2+> release from intracellular Ca^<2+> stores was prevented by ATP. Formation of inositol trisphosphate induced by CCh stimulation was strongly attenuated in the presence of extracellular ATP, suggesting that the effect of ATP on the CCh-induced [Ca^<2+>]_i response was the result of a decreased phosphoinositide hydrolysis. Extracellular ATP had no effect on the CCh-induced increase in [Ca^<2+>] j in rat lacrimal acinar cells that lack the purinergic receptors. This result supports the view that the inhibitory effect of ATP on the CCh-induced [Ca^<2+>]_i response in parotid acinar cells is mediated through activation of the purinergic receptros. In rat parotid acinar cells, the purinergic receptors may play a role in modulating the activity of muscarinic receptors. | |||||
| 言語 | en | |||||
| 雑誌書誌ID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN0008135X | |||||
| 書誌情報 |
ja : 東日本歯学雑誌 巻 16, 号 2, p. 199-204, 発行日 1997-12-30 |
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