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カルシウム拮抗薬のもつ局所麻酔様作用
https://hsuh.repo.nii.ac.jp/records/8426
https://hsuh.repo.nii.ac.jp/records/84263f60b72e-9b89-42d3-9459-fdf64eb629cb
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
カルシウム拮抗薬のもつ局所麻酔様作用 (402.3 kB)
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| Item type | 紀要論文(ELS) / Departmental Bulletin Paper(ELS)(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 1999-06-30 | |||||
| タイトル | ||||||
| タイトル | カルシウム拮抗薬のもつ局所麻酔様作用 | |||||
| 言語 | ja | |||||
| タイトル | ||||||
| タイトル | Local Anesthetic Effects of Calcium Antagonists (Diltiazem, Verapamil, and Nicardipine) on Extracted Rabbit Vagus Nerve | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Calsium Antagonist | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Local Anesthetic Action | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | NMR-Spectroscopy | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Nerver Blockage | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| ページ属性 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | P(論文) | |||||
| 言語 | ja | |||||
| 記事種別(日) | ||||||
| ja | ||||||
| 原著 | ||||||
| 記事種別(英) | ||||||
| en | ||||||
| ORIGINAL | ||||||
| 著者名(日) |
國分, 正廣
× 國分, 正廣× 小田, 和明× 河合, 拓郎× 大桶, 華子× 加藤, 元康× 工藤, 勝× 新家, 昇 |
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| 著者所属(日) | ||||||
| ja | ||||||
| 北海道医療大学歯学部歯科麻酔学講座 | ||||||
| 著者所属(日) | ||||||
| ja | ||||||
| 北海道医療大学薬学部化学講座 | ||||||
| 著者所属(英) | ||||||
| en | ||||||
| Department of Dental Anesthesiology, Faculty of Dentistry, Health Sciences University of Hokkaido | ||||||
| 著者所属(英) | ||||||
| en | ||||||
| Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido | ||||||
| 抄録(英) | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The local anesthetic effects of calcium antagonists (diltiazem, verapamil, and nicardipine) on extracted rabbit vagus nerve (Fig. 1) and their binding ability to the phospholipid membrane model were examined by ^1H-NMR spectroscopy. Effective concentrations of these drugs for vagus nerve blockage were examined with 12～14V electrical stimuli. The minimum effective concentration of calcium antagonist which completely blocked the compound action potential was 0.5mM for diltiazem, and 0.2mM for verapamil. Nicardipine did not show any conduction blocking effect at 1.0mM. Local anesthetic effects of ditiazem and verapamil were characterized by a slower onset (over 20 min) and longer duration (over 30 min) compared with lidocaine (Table 1). The local anesthetic effects of dilitiazem and verapamil may be due to the SA and AV nodal blocking effect and reductions in the ventricular rate by these drugs. However, in the SA and AV nodes, depolarization is largely dependent on the movement of Ca^<2+> through the slow channel. The results of ^1H-NMR spectroscopy indicated that poor electrostatic binding with the phospholipid membrane occured only with diltiazem (Fig. 2). Local anesthetic effects of calcium antagonists may not be based on electrostatic binding with the nerve membrane as in the case of local anesthetics. | |||||
| 言語 | en | |||||
| 雑誌書誌ID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN0008135X | |||||
| 書誌情報 |
ja : 東日本歯学雑誌 巻 18, 号 1, p. 141-146, 発行日 1999-06-30 |
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