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<原著>Growth Differentiation Factor-5/β-TCP複合体によるビーグル犬前頭洞内骨形成に関する実験的研究
https://hsuh.repo.nii.ac.jp/records/8711
https://hsuh.repo.nii.ac.jp/records/8711558376bf-6b5c-41ea-93ff-ee26270324a0
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
<原著>Growth Differentiation Factor-5/β-TCP複合体によるビーグル犬前頭洞内骨形成に関する実験的研究 (1.5 MB)
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| Item type | 紀要論文(ELS) / Departmental Bulletin Paper(ELS)(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2002-06-30 | |||||
| タイトル | ||||||
| タイトル | <原著>Growth Differentiation Factor-5/β-TCP複合体によるビーグル犬前頭洞内骨形成に関する実験的研究 | |||||
| 言語 | ja | |||||
| タイトル | ||||||
| タイトル | <ORIGINAL REPORT>An experimental study of bone formation in the beagl dog frontal sinus induced by β-tricalcium phosphate matrix with growth differentiation factor-5 implants | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | GDF-5 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | β-TCP | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Sinus Lift | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Beagle Dog | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Frontal Sinus | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| ページ属性 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | P(論文) | |||||
| 言語 | ja | |||||
| 著者名(日) |
國安, 宏哉
× 國安, 宏哉× 広瀬, 由紀人× 賀来, 亨× 金子, 昌幸× 田隈, 泰信 |
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| 著者所属(日) | ||||||
| ja | ||||||
| 北海道医療大学歯学部歯科補綴学第二講座/北海道医療大学歯学部口腔病理学講座/北海道医療大学歯学部歯科放射線学講座/北海道医療大学歯学部口腔生化学講座 | ||||||
| 著者所属(英) | ||||||
| en | ||||||
| Department of Fixed Prosthodontics, School of Dentistry, Health Sciences University of Hokkaido/Deparment of Oral Pathofogy, School of Dentistry, Health Sciences University of Hokkaido/Deparment of Dentai Radiology, School of Dentistry, Health Sciences University of Hokkaido/Deparment of Oral Biochemistry, School of Dentistry, Health Sciences University of Hokkaido | ||||||
| 抄録(英) | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | This study assessed the efficacy and technical feasibility of inducing bone formation in an animal model of maxillary sinus floor augmentation using β-tricalcium phosphate (β-TCP) matrix with recombinant human growth differentiation factor 5 (rhGDF-5). The study used adult beagle dogs weighing 10 to 12 kg. The composite of the β-TCP matrix with rhGDF-5 (rhGDF-5/β-TCP) is made of approximately 300 micro-meter β-TCP particles and rhGDF-5 which contained 500 micro-gram per gram of β-TCP particles. Exposure of the frontal sinus was carried out bilaterally, with one sinus receiving 2 grams of the rhGDF-5/β-TCP implant and the other receiving 2 grams of β-TCP particles alone (control) . The frontal sinuses were excised 1, 2, 4, 8, 12, and 16 weeks after surgery and the bone formation in response to the rhGDF-5/β-TCP implant was evaluated histologically. At 2 weeks of postimplantation in the site implanted with rhGDF-5/β-TCP, new cancellous bone appeared at localized sites on the original bone surface. In contrast, there was no evidence of new bone formation at the control implant site. At 8 weeks, interconnected trabecular structure and bone marrow were found within the sinus of the rhGDF-5/β-TCP implants. Cartilage was not found in any region and residues of carrier β-TCP were seen in the middle area. At the site of the received controlimplants, the bulk of implanted β-TCP particles remained within the sinus. At 12 weeks, the large new trabecular bone extended to the original bone surfaces in the center of the implant site of the rhGDF-5/β-TCP implants. At the control site, little new cancellous bone was formed in the middle area. At 16 weeks, rhGDF-5/β-TCP implants increased new bone formation with the lapse of time and β-TCP particles were almost all absorbed. The present study showed that rhGDF-5 coated on β-TCP matrix successfully it maybe induced bone formation in the floor of the frontal sinus in a suitable animal model. Therfore, we conclude that the β-TCP matrix with rhGDF-5 could provide an acceptable biomaterial for maxillary sinus floor augmentation. | |||||
| 言語 | en | |||||
| 雑誌書誌ID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN0008135X | |||||
| 書誌情報 |
ja : 東日本歯学雑誌 巻 21, 号 1, p. 11-23, 発行日 2002-06-30 |
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